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HSP90AA1 — KDR

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: Hsp90 (HSP90AA1) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: Hsp90 (HSP90AA1) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: Hsp90 (HSP90AA1) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: Hsp90 (HSP90AA1) → VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: ROCK (ROCK1) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → RhoA (RHOA) (modification, collaborate) Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: None → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: RHOA/GDP complex (RHOA) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: mutant phenotype
• NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → FAK (PTK2) (modification, activates) Le Boeuf et al., Mol Biol Cell 2006, Abedi et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: HSP90AA1 → KDR (reaction) Schaller et al., Biochem J 2001, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
• Reactome Reaction: HSP90AA1 → KDR (indirect_complex) Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: KDR — HSP90AA1 (in vivo) Le Boeuf et al., J Biol Chem 2004

Text-mined interactions from Literome