Sheehan et al., Am J Physiol Regul Integr Comp Physiol 2007
:
We have focused on Pak1 regulation of protein phosphatase 2A (PP2A) , which is abundant in cardiac muscle, thereby mediating dephosphorylation of sarcomeric proteins and sensitizing the myofilaments to Ca ( 2+ )
Ai et al., Cardiovasc Res 2011
(Heart Failure) :
PAK1 overexpression in both rabbit myocytes and HEK293-Cx43 cells significantly increased PP2A activity ( globally and at the level of Cx43 ), increased dephosphorylated Cx43, and markedly reduced intercellular dye coupling