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NOTCH3 — NOTCH4

Text-mined interactions from Literome

Liu et al., Circ Res 2009 : Interestingly, we found that the expression of NOTCH3 is dependent on Notch signaling, because the gamma-secretase inhibitor DAPT blocked its upregulation
Jiao et al., Clin Exp Immunol 2011 : Selective inhibition of Notch signalling mediated by Notch3 or Delta-like1 may offer a new strategy for the treatment of RA
Funahashi et al., Vascular cell 2011 : Overexpression of VEGF induced Notch4 and the Notch ligand, Dll4, activated Notch signaling, and altered endothelial cell morphology in a fashion similar to that induced by Notch activation
Serafin et al., J Pathol 2011 (Cell Transformation, Neoplastic...) : Altogether, these findings indicate that Notch3 can modulate the tumourigenic properties of CRC cells and contributes to sustained Notch activity in DLL4 expressing tumours
Xiang et al., Clinical lymphoma, myeloma & leukemia 2012 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : These facts suggest that downregulating expression of Notch3 could attenuate the Notch signaling activity in T-ALL
Van de Walle et al., J Exp Med 2013 : Jagged2 induces the strongest Notch signal through interactions with both Notch1 and Notch3 , whereas Delta-like 4 primarily binds Notch1