Gene interactions and pathways from curated databases and text-mining

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MMP9 — RAC1

Text-mined interactions from Literome

Zhuge et al., J Biol Chem 2001 (Carcinoma, Squamous Cell...) : The Rac1 dependent MMP-2 activation occurred in a cell associated fashion and required MMP activities
Binker et al., Biochem Biophys Res Commun 2009 (Pulmonary Disease, Chronic Obstructive) : LPS stimulated MUC5AC production involves Rac1 dependent MMP-9 secretion and activation in NCI-H292 cells
Murthy et al., J Biol Chem 2010 (MAP Kinase Signaling System...) : To investigate the contribution of aberrant matrix degradation, we addressed the role of Rac1 in regulating expression of macrophage-specific MMP-9 ( matrix metalloproteinase-9 ) ... Rac1 regulates MMP-9 transcription via mitochondrial H ( 2 ) O ( 2 ) generation, providing a potential mechanism by which Rac1 null mice fail to develop pulmonary fibrosis
Chan et al., Cardiovasc Ther 2012 (Diabetes Mellitus) : Under high glucose conditions, simvastatin dose-dependently inhibited VSMC migration, decreased PI3K/Akt pathway activity, reduced c-Raf and Ras expression, increased RhoB but not RhoA, Rac1 , and Cdc2 expression, dose-dependently inhibited MMP-2, but not MMP-9 , activity, and dose-dependently inhibited NF-?B activity
Murthy et al., Biochem J 2012 : We determined the effects of Rac1 and ERK on MMP-9 expression driven by SP-1WT ( wild-type ) and the SP-1 mutants T578A, S586A and S587A ... However, constitutively active Rac1 suppressed MMP9 promoter activity in cells expressing SP-1WT, SP-1T578A and SP-1S587A, but not SP-1S586A
Stallings-Mann et al., Sci Transl Med 2012 (Adenocarcinoma...) : We show that expression of mouse Rac1b in lung epithelial cells of transgenic mice stimulated EMT and spontaneous tumor development and that activation of EMT by MMP induced expression of Rac1b gave rise to lung adenocarcinoma in the transgenic mice through bypassing oncogene induced senescence
Serratì et al., Arthritis Rheum 2013 (Scleroderma, Systemic) : Motility increase required Rac1 activation and RhoA inhibition and was inhibited by an MMP inhibitor