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MAPK3 — REN
Text-mined interactions from Literome
Huang et al., Kidney Int 2007
:
We tested the hypothesis that
renin receptor activation, in turn,
activates the
extracellular-signal regulated kinase 1 and 2 ( ERK1/2 ) of the mitogen activated protein kinase system in mesangial cells
Feldt et al., J Am Soc Nephrol 2008
(Hypertension) :
Preincubation with the HRP or aliskiren did not prevent
renin- and prorenin
induced extracellular signal regulated kinase 1/2 phosphorylation, whereas the MAP kinase kinase (MEK1/2) inhibitor PD98059 prevented both
Feldman et al., Hypertension 2008
(Albuminuria...) :
In human mesangial cells, aliskiren ( 0.1 micromol/L to 10 micromol/L ) did not inhibit binding of ( 125 ) I-renin to the ( pro ) renin receptor, nor did it alter the
activation of
extracellular signal regulated kinase 1/2 by
renin ( 20 nmol/L ) preincubated with aliskiren ( 100 nmol/L ) or affect gene expression of the ( pro ) renin receptor
Advani et al., Hypertension 2009
(Disease Models, Animal) :
In collecting duct/distal tubule lineage Madin-Darby canine kidney cells,
extracellular signal regulated kinase 1/2 phosphorylation,
induced by either
renin or prorenin, was attenuated by the selective vacuolar H ( + ) -ATPase inhibitor bafilomycin