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CD80 — HLA-DRA

Pathways - manually collected, often from reviews:

• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, collaborate)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, activates)
  Woods et al., EMBO J 2001, Wilcox et al., J Biol Chem 2003, August et al., Proc Natl Acad Sci U S A 1994, Raab et al., Proc Natl Acad Sci U S A 1995, Gibson et al., J Biol Chem 1996, Heyeck et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, activates)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, activates)
  Raab et al., Proc Natl Acad Sci U S A 1995
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Gutzmer et al., J Immunol 2003 : IL-18 strongly up-regulated CD54 on MoDC, whereas the effect on MHC class II , CD83, and CD86 was only moderate and the expression of CD40 and CD80 was not affected
Bimczok et al., Vet Res 2007 : Ctx promoted the development of a semi-mature DC phenotype, with decreased levels of MHC class II and CD40, but increased CD80/86 expression
Vigne et al., Blood 2011 : In addition, IL-36ß enhanced the expression of CD80 , CD86, and MHC class II by BMDCs. IL-36 also induced the production of IFN-?, IL-4, and IL-17 by CD4 ( + ) T cells and cultured splenocytes