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NOS3 — SRC
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Davis et al., Circ Res 2001
(MAP Kinase Signaling System) :
Thus,
c-Src plays a central role in modulation of
eNOS expression in response to shear stress via divergent pathways involving a short-term increase in eNOS transcription and a longer-term stabilization of eNOS mRNA
Davis et al., Am J Physiol Heart Circ Physiol 2003
:
Role of
c-Src in regulation of endothelial
nitric oxide synthase expression during exercise training
Takenouchi et al., Oncol Rep 2004
(Breast Neoplasms) :
In contrast, non myristoylated form of
v-Src , G2Av-Src and a kinase-inactive mutant of v-Src, K295Mv-Src, could not
activate NOS3 phosphorylation ... Taken together, our results suggest that active, membrane bound form of
Src can
induce constitutive phosphorylation of
NOS3
Xu et al., Hypertension 2004
:
An
Src kinase inhibitor, pp2, and MEK inhibitor, PD98059,
blocked the ERK1/2 phosphorylation and
eNOS expression
Cai et al., J Mol Cell Cardiol 2004
:
Inhibition of
c-Src ( essential for LSS upregulation of eNOS )
had no effect on OSS upregulation of
eNOS
Fulton et al., J Biol Chem 2005
(Inflammation) :
Taken together, these data indicate that
Src mediated tyrosine phosphorylation of
eNOS at Tyr-83 modulates eNOS activity in endothelial cells
Nakaya et al., J Med Invest 2007
:
SH-6 ( 10 microM ), an Akt inhibitor, and wortmannin, a PI3-kinase inhibitor, completely blocked activation of K ( Ca ) channels by ginsenoside Re, indicating that it activates
eNOS via a
c-Src/PI3-kinase/Akt dependent mechanism
Li et al., Proc Natl Acad Sci U S A 2007
:
Only membrane
c-Src is structurally and functionally
involved in E2-induced
eNOS activation
Fulton et al., Circ Res 2008
:
Agonist stimulation of
eNOS Tyr83 phosphorylation as well as agonist stimulation of endothelial NO release in BAECs is
blocked by Src kinase inhibition by either 4-amino-5- ( 4-chlorophenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ( PP2 ) or by dominant negative
Src ... Moreover, our results demonstrate an important role for
Src mediated phosphorylation of
eNOS at Tyr83 in agonist stimulation of eNOS activation and vascular relaxation
Tyryshkin et al., J Biol Chem 2010
(Disease Models, Animal...) :
Src kinase mediated phosphorylation
stabilizes inducible
nitric-oxide synthase in normal cells and cancer cells
Chen et al., Mol Biol Cell 2012
:
Taken together, these data suggest that activation of eNOS promotes
Src dependent Cav-1-Tyr-14 phosphorylation and
eNOS/Cav-1 binding, that is, eNOS feedback inhibition
Rattmann et al., J Vasc Res 2012
:
Natural product extract of Dicksonia sellowiana induces endothelium dependent relaxations by a redox-sensitive
Src- and Akt dependent
activation of
eNOS in porcine coronary arteries
Slomiany et al., Inflammopharmacology 2013
(Helicobacter Infections...) :
Further, the effect of ghrelin of the LPS induced changes was reflected in the increase in
Src/Akt dependent
cNOS activation through phosphorylation and the inhibition of cNOS mediated IKK-ß S-nitrosylation
Kurita et al., Food Funct 2013
(Cardiovascular Diseases) :
( - ) -Epigallocatechin-3-O-gallate ( EGCg ) has been shown to induce endothelium dependent nitric oxide ( NO ) -mediated relaxation via the redox-sensitive
Src/PI3-kinase/Akt dependent phosphorylation of
endothelial NO synthase (eNOS)