◀ Back to CCND1
CCND1 — MAP2K1
Text-mined interactions from Literome
Terada et al., Nephrol Dial Transplant 1999
:
In contrast, constitutive active
MKK1 , the classical p42/44 MAPK activator,
increased cyclin D1 promoter activity and level of protein
Terada et al., Kidney Int 1999
:
In contrast, overexpression of the active form of
MKK1 , the classic MAPK-activator, MKK1
increased cyclin D1 promoter activity and protein level, as well as the percentages of S and G2/M phases
Rimerman et al., J Biol Chem 2000
:
The ability of a dominant negative cyclin D1 mutant, D1-T156A, to inhibit Wnt1/MEK1 dependent S-phase entry suggests that
cyclin D1 is a critical downstream
target for Wnt1- and
MEK1 dependent cellular proliferation
Lotfi et al., Endocr Res 2000
(Adrenal Cortex Neoplasms) :
But, the
MEK1 inhibitor, PD98059 ( 50microM ),
inhibits cFos and
cyclin D1 induction and DNA synthesis stimulation by both ACTH39 and FGF2, suggesting that ERK1/2 activation mediates the strong and the weak mitogenic effect of, respectively, FGF2 and ACTH39
Nofer et al., Thromb Haemost 2001
(MAP Kinase Signaling System) :
PD98059, an inhibitor of
MEK-1 blocked the mitogenic activity of HDL and
cyclin D1 expression
Huynh et al., Int J Oncol 2004
(Carcinoma, Hepatocellular...) :
Ectopic expression of activated
MEK1 in HepG2 cells
increased cyclin D1 and Cdk-2 expression, phosphorylation of pRB at Ser780 and Ser795, and percentage of cells in S phase
Ding et al., J Gastroenterol Hepatol 2008
(Helicobacter Infections...) :
MEK1/2 inhibition increased p21, p27 and cyclin E and JNK inhibition additionally
increased cyclin D1 expression
Lavoie et al., J Biol Chem 1996
:
Conversely, activation of this signaling pathway by expression of a constitutively active
MKK1 mutant dramatically
increased cyclin D1 promoter activity and cyclin D1 protein expression, in a growth factor independent manner
Diehl et al., Genes Dev 1998
:
In contrast, Ras mutants defective in PI3K signaling, or constitutively active
mitogen activated protein kinase-kinase ( MEK1 ) mutants that act downstream of Ras to activate extracellular signal regulated protein kinases ( ERKs ), can not
stabilize cyclin D1
Aziz et al., Mol Cell Biol 1999
:
Activation of Raf, v-Src, and
MEK1 led to induced expression of c-Myc and
cyclin D1