◀ Back to PIK3R1
KIT — PIK3R1
Pathways - manually collected, often from reviews:
-
KEGG Pathways in cancer:
KIT
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Acute myeloid leukemia:
KIT
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
Reactome Reaction:
KIT
→
PIK3R1
(indirect_complex)
Chian et al., Blood 2001*, Rönnstrand et al., Cell Mol Life Sci 2004*, Reber et al., Eur J Pharmacol 2006, Sun et al., J Biol Chem 2008
-
Reactome Reaction:
KIT
→
PIK3R1
(reaction)
Chian et al., Blood 2001*, Rönnstrand et al., Cell Mol Life Sci 2004*, Reber et al., Eur J Pharmacol 2006, Sun et al., J Biol Chem 2008
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
KIT
—
PIK3R1
De Sepulveda et al., EMBO J 1999
-
IRef Bind_translation Interaction:
KIT
—
PIK3R1
(two hybrid)
De Sepulveda et al., EMBO J 1999
-
IRef Biogrid Interaction:
PIK3R1
—
KIT
(physical association, affinity chromatography technology)
Zhu et al., Oncogene 2007*
-
IRef Biogrid Interaction:
PIK3R1
—
KIT
(direct interaction, two hybrid)
Yokouchi et al., Oncogene 1997*
-
IRef Biogrid Interaction:
PIK3R1
—
KIT
(direct interaction, pull down)
van Dijk et al., Blood 2000
-
IRef Biogrid Interaction:
PIK3R1
—
KIT
(direct interaction, two hybrid)
De Sepulveda et al., EMBO J 1999
-
IRef Biogrid Interaction:
PIK3R1
—
KIT
(physical association, affinity chromatography technology)
Serve et al., J Biol Chem 1994*
-
IRef Hprd Interaction:
PIK3R1
—
KIT
(in vivo)
Serve et al., J Biol Chem 1994*
-
IRef Hprd Interaction:
PIK3R1
—
KIT
(in vitro)
Serve et al., J Biol Chem 1994*
-
IRef Innatedb Interaction:
KIT
—
PIK3R1
(unknown, -)
Lennartsson et al., Exp Cell Res 2003
-
IRef Intact Interaction:
KIT
—
PIK3R1
(association, coimmunoprecipitation)
Domchek et al., Biochemistry 1992*
-
IRef Intact Interaction:
KIT
—
PIK3R1
(association, coimmunoprecipitation)
Herbst et al., Biochemistry 1995*
-
IRef Ophid Interaction:
KIT
—
PIK3R1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Ueda et al., Blood 2002
(Calcium Signaling) :
In Y719F, the binding of phosphatidylinositol 3'-kinase (PI3K) to
KIT was lost and KIT mediated cell migration and Ca ( 2+ ) mobilization were
suppressed by PI3K chemical inhibitors or dominant negative
PI3K , suggesting the involvement of Y719 mediated PI3K pathway in cell migration
Koma et al., Lab Invest 2005
:
KIT-Y719F does not
activate PI3-K , whereas KIT-Y821F does
Zhu et al., Oncogene 2007
(Gastrointestinal Stromal Tumors) :
Activated signaling intermediates were identified by immunoaffinity purification of tyrosine phosphorylated proteins in GIST cells before and after treatment with KIT inhibitors, and these analyses show that GRB2, SHC, CBL and MAPK activation are largely KIT dependent in GISTs, whereas
PI3-K , STAT1 and STAT3 activation are partially
KIT dependent