Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — FGF2

Text-mined interactions from Literome

Treichel et al., Genes Dev 2003 : We present evidence that mBtd is required during early limb development to maintain, but not to initiate Wnt/beta-catenin dependent FGF , Shh, and BMP mediated signaling
Israsena et al., Dev Biol 2004 : FGF2 increases beta-catenin signaling through several different mechanisms including increased expression of beta-catenin mRNA, increased nuclear translocation of beta-catenin, increased phosphorylation of GSK-3beta, and tyrosine phosphorylation of beta-catenin ... Overexpression of beta-catenin in the presence of FGF2 helps to maintain neural progenitor cells in a proliferative state
Hirabayashi et al., Development 2004 : Overexpression of Wnt7a or of a stabilized form of beta-catenin in mouse cortical NPC cultures induced neuronal differentiation even in the presence of Fgf2 , a self-renewal promoting factor in this system
Kanda et al., J Cell Biochem 2005 : FGF-2 induced association of beta-catenin with TCF-4 and up-regulation of fibronectin in IBE cells, but not in KDFyn cells ... FGF-2 induced tyrosine phosphorylation of beta-catenin , and association with TCF-4 was increased in IBE cells, but not in KDFyn cells
Maegawa et al., Development 2006 : By contrast, when FGF signaling is inhibited, beta-catenin did not induce goosecoid and chordin, repress bmp4 expression or induce a dorsal axis ... These results demonstrate that FGF signaling is necessary for beta-catenin induction of the zebrafish organizer
Katoh et al., Cancer Biol Ther 2007 (Helicobacter Infections...) : WNT-beta-catenin-TCF/LEF signaling induces upregulation of MYC, CCND1, WISP1, FGF20 , JAG1 and DKK1 genes
Ambrosetti et al., Mol Cell Biol 2008 : FGF did not significantly affect the activation of beta-catenin , although it reduced both the expression of TCF/LEF factors and their induction by Wnt. Microarray analysis using osteoblasts treated with Wnt3a and FGF alone or in combination showed that about 70 % of the genes induced by Wnt3a were downregulated by combined FGF treatment
Shimizu et al., Mol Cell Biol 2008 : We demonstrate that FGF2 signaling through phosphatidylinositol 3 kinase activation inactivates glycogen synthase kinase 3beta ( GSK3beta ) and leads to the accumulation of beta-catenin in a manner different from that in the Wnt canonical pathway
Ding et al., J Cell Physiol 2010 : To understand the importance of PI3-K activation, activation of Wnt/beta-catenin by FGF-2 was investigated