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CRYAB — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Liu et al., Biochem Biophys Res Commun 2007
:
alphaB-Crystallin interacted with p53, a proapoptotic protein, during cell apoptosis and such protein interaction mainly occurred in the cytoplasm of the cells, suggesting that the interaction of
alphaB-crystallin with p53 might
prevent the translocation of
p53 from cytoplasm to mitochondria
Evans et al., Breast Cancer Res Treat 2010
(Carcinoma, Transitional Cell...) :
Induction of the small heat shock protein
alphaB-crystallin by genotoxic stress is
mediated by
p53 and p73 ... DeltaNp73 was dramatically induced by
p53 in a TAp73 dependent manner, and silencing p73
suppressed the transcriptional activation of
alphaB-crystallin by p53
Deng et al., BMB Rep 2010
:
Transient transfection assays indicated that overexpression of LBH or alphaB-crystallin reduced the transcriptional activities of p53 and p21, respectively, Overexpression of both
alphaB-crystallin and LBH together
resulted in a stronger repression of the transcriptional activities of p21 and
p53 ... These results showed that the interaction of LBH and
alphaB-crystallin may
inhibit synergistically the transcriptional regulation of
p53 and p21