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HSP90AA1 — MATK
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Habib et al., Arch Biochem Biophys 2009
(MAP Kinase Signaling System) :
Down-regulation of ATM and
Chk2 by their small interfering RNAs ( siRNAs ) attenuated the arsenite induced phosphorylation of p53 and
restored Hsp90beta mRNA levels
Jacquemont et al., Molecular cancer 2012
(Neoplasms...) :
In addition, geldanamycin (
HSP90 inhibitor ) and two
CHK1 inhibitors ( UCN-01 and SB218078 ) exhibited a significantly stronger synergism with cisplatin in FA-proficient cells when compared to FA-deficient cells, suggesting a contribution of their FA pathway inhibitory activity to cisplatin sensitization
Haarberg et al., Mol Cancer Ther 2013
(Melanoma) :
In vitro,
HSP90 inhibition
led to the degradation of ARAF, CRAF, Wee1,
Chk1 , and cdc2 and was associated with decreased mitogen activated protein kinase ( MAPK ), AKT, mTOR, and c-jun NH2 kinase ( JNK ) signaling