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SMAD1 — VEGFA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Nakagawa et al., American journal of physiology. Renal physiology 2004
(Anoxia) :
Rat proximal tubular ( NRK52E ) cells treated with TGF-beta under normoxic conditions secreted
VEGF at 24 h, and this was significantly
reduced by blocking
Smad activation by overexpressing the inhibitory Smad7 or by blocking p38 and ERK1/2 MAP kinase activation or protein kinase C activation with specific inhibitors
Lee et al., Cell Tissue Res 2012
(Glomerulonephritis, Membranous...) :
Furthermore, activated
TGF-ß/Smad signaling by podocytes may
induce connective tissue growth factor and
vascular endothelial growth factor overexpression, which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis
Bai et al., Development 2013
(Truncus Arteriosus, Persistent...) :
Our findings indicate that
Smad directly binds to Vegfa chromatin and
represses Vegfa transcriptional activity