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EPO — GATA1

Text-mined interactions from Literome

Ogilvie et al., J Biol Chem 2000 : In erythroid progenitor cells, Epo stimulates induction of transcription factor GATA-1 and EpoR ; in C2C12 cells, GATA-3 and EpoR expression are induced
Zhao et al., Blood 2006 : The PI3-kinase/AKT signaling pathway is identified as a mediator of Epo induced phosphorylation of GATA-1
Chiba et al., Nucleic Acids Res 1991 (Leukemia, Erythroblastic, Acute) : Taken together with other observations, these results suggested the following scheme of erythroid differentiation : 1 ) GATA-1 is expressed in the early stage of blood cell development ; 2 ) GATA-1 transactivates the erythropoietin receptor gene ; 3 ) erythropoietin binds its receptor and the receptor mediated signals enhance GATA-1 gene expression in erythroid progenitor cells ; and 4 ) GATA-1 finally transactivates hemoglobin synthesis related genes and globin genes in relatively matured erythroid cells
Horie et al., Int J Sports Med 2011 : Expression of the ERYTHROPOIETIN gene is negatively controlled by the transcription factor GATA binding protein ( GATA )
Delehanty et al., Blood 2012 (Anemia) : Here we show that erythropoietin regulates GATA1 through protein kinase D activation, promoting histone deacetylase 5 (HDAC5) dissociation from GATA1, and subsequent GATA1 acetylation
Katakura et al., Dev Comp Immunol 2013 : Recombinant goldfish erythropoietin induced proliferation of progenitor cells in a dose dependent manner, and up-regulated the expression of erythroid transcription factors gata1 and lmo2 in progenitor cells
Lin et al., PloS one 2013 : Here, we demonstrate that phosphorylation of GATA-1 at serine ( 26 ) is also transiently induced in cells of the erythroid lineage ( primary erythroblasts and erythrocyte committed progenitors [ EPs ] ) by erythropoietin (EPO) , the principal cytokine regulating erythropoiesis
Busfield et al., Eur J Biochem 1995 : The major erythroid DNA binding protein GATA-1 is stimulated by erythropoietin but not by chemical inducers of erythroid differentiation ... Premature removal of erythropoietin from culture resulted in submaximal GATA-1 , globin, and hemoglobin production
Aird et al., J Biol Chem 1994 : The functional significance of the inhibition of preinitiation complexes is supported by in vitro transcription assays in which transcription from the PF4 and erythropoietin core promoters is suppressed by GATA-1
Nicolis et al., Exp Hematol 1993 : Erythroid differentiation involves the activation of a number of erythroid-specific genes, most of which, including the globin genes and the erythropoietin receptor (Epo-R) gene, are, at least in part, regulated by the transcription factor GATA-1
Hoefsloot et al., Blood 1997 (Myelodysplastic Syndromes) : Epo dependent DNA synthesis as well as induction of GATA-1 binding activity in marrow cells from 15 MDS cases were severely reduced as compared with normal bone marrow ( NBM )
Moroni et al., Biochem Biophys Res Commun 1997 : However, when grown in vitro, they rapidly express GATA-1 from the testis promoter in the presence of Erythropoietin (Epo) but not in that of other growth factors
Sharlow et al., Blood 1997 (Leukemia, Erythroblastic, Acute) : No effects of EPO on levels of HCP, Syp, Stat5, the EPO receptor, or GATA-1 expression were observed during induced differentiation
Joneja et al., Blood 1997 : In FDC2-ER cells, the ectopic expression of GATA-1 had no detectable effect on Epo inhibition of apoptosis