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IL8 — TP53

Text-mined interactions from Literome

Yuan et al., J Clin Oncol 2002 (Carcinoma, Non-Small-Cell Lung...) : This result indicates that aberrant p53 expression may play a significant role in regulation of VEGF and IL-8 expression and be involved in controlling angiogenesis and explains the adverse prognosis of cancers with high aberrant p53 expression
Hidaka et al., J Exp Clin Cancer Res 2005 (Neoplasms) : These results show that wt-p53 gene transfer inhibits IL-8 production and NF-kappaB transcription activity in cancer cells and suggest that constitutive IL-8 production in cancer cells is associated with mutation of p53
Dreij et al., Carcinogenesis 2010 (Inflammation) : We confirmed this hypothesis by showing that p53 dependent signaling through c-jun N-terminal kinase ( JNK ) led to increased cJun-Ser63 phosphorylation and that inhibition of JNK mediated cJun activation using p53- or JNK-specific inhibitors significantly reduced IL gene expression and subsequent production of IL8