Kino et al., Diabetes 2005
(Acquired Immunodeficiency Syndrome...) :
This HIV-1 protein also interfered with insulin induced coprecipitation of 14-3-3 and Foxo3a in vivo and antagonized the negative effect of insulin on Foxo3a induced transactivation of a FOXO-responsive promoter
Lynch et al., Mol Cancer Res 2005
(Disease Progression...) :
Together, reduced FOXO3a expression coupled to FOXO3a hyperphosphorylation would suppress FOXO transcriptional activity
Essaghir et al., J Biol Chem 2009
:
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors ... Conversely, ectopic FOXO3 activation blocked the proliferation of fibroblasts and induced the expression of FOXO1, FOXO4 , and p27-KIP1