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IRF1 — TNF

Text-mined interactions from Literome

Rödel et al., Med Microbiol Immunol 1999 : Tumor necrosis factor-alpha (TNF-alpha) stimulation enhanced IRF-1 mRNA levels in infected cells and was required to detect IRF-1 protein by immunoblotting
Mori et al., J Cell Biochem 1999 : Induction of transcription factor interferon regulatory factor-1 by interferon-gamma (IFN gamma) and tumor necrosis factor-alpha (TNF alpha) in FRTL-5 cells ... In the present study, we used FRTL-5 rat thyroid cells to examine the effects of IFN gamma and TNF alpha on gene expression of transcription factor interferon regulatory factor-1 (IRF-1) , which is involved in mediating the effects of these cytokines in a number of cell types
Suter et al., Biol Reprod 2001 : Furthermore, IFNgamma and TNFalpha treatment elevated levels of IRF-1 within 2 h. TNFalpha induced increases in the levels of IRF-1 were transient, whereas the levels of IRF-1 in response to IFNgamma treatment remained elevated at 48 h
Ochi et al., Eur J Immunol 2002 : Hyperosmotic medium also inhibited the expression of IRF-1 induced by TNF-alpha or IFN-gamma
Andoh et al., J Immunol 2002 : EMSAs demonstrated that IL-17 did not modulate the TNF-alpha induced NF-kappaB DNA binding activity, but markedly decreased TNF-alpha induced IFN regulatory factor-1 (IRF-1) DNA binding activity
Tliba et al., J Biol Chem 2003 (Inflammation) : In this study, TNFalpha in a time dependent manner activated both janus tyrosine kinase 1 and Tyk2 tyrosine kinase and increased the nuclear translocation of interferon-regulatory factor-1 , STAT1, and STAT2 in human airway smooth muscle cells
Gira et al., J Invest Dermatol 2003 : Induction of interferon regulatory factor 1 expression in human dermal endothelial cells by interferon-gamma and tumor necrosis factor-alpha is transcriptionally regulated and requires iron
Dagia et al., J Immunol 2004 : We found that compound 10 1 ) dramatically inhibits TNF-alpha induced VCAM-1 mRNA and protein expression in human aortic endothelial cells ( HAEC ), has a relatively modest inhibitory effect on TNF-alpha induced E-selectin expression and has no effect on ICAM-1 expression ; 2 ) significantly reduces TNF-alpha induced monocytic ( U937 ) cell adhesion to HAEC under in vitro flow conditions similar to that present in vivo ; 3 ) inhibits TNF-alpha induced IFN regulatory factor-1 binding to VCAM-1 promoter ; and 4 ) reduces TNF-alpha induced IRF-1 expression in HAEC
Stangl et al., J Nutr 2005 : Phloretin did not affect TNF-alpha stimulated activation of nuclear factor kappaB (NF-kappaB) but inhibited activation of interferon regulatory factor 1 , a transcription factor involved in the regulation of endothelial cell adhesion molecule expression
Huang et al., J Biomed Sci 2005 : Interestingly, TNF-alpha induced interferon regulatory factor (IRF)-1 activation was significantly inhibited by all calcium mobilizing agents, BK, Thr and Tg
Bennett et al., Blood 2006 (Inflammation...) : Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Rizvi et al., J Surg Res 2006 (Acute Disease...) : We hypothesized that TNF-alpha would induce IRF-1 and p53 protein binding in pancreatic acinar cells and that PYY would attenuate the effect
Tliba et al., Am J Respir Cell Mol Biol 2008 : Interestingly, the capacity of fluticasone to completely inhibit TNF-alpha induced IRF-1 expression, IRF-1 DNA binding, and transactivation activities was completely lost in cells exposed to TNF-alpha and IFN-gamma in combination
Paun et al., J Biol Chem 2008 (Newcastle Disease) : In addition, IRF-5 regulates TNFalpha but not type I interferon gene transcription in Newcastle disease virus infected peritoneal macrophages
Hu et al., J Leukoc Biol 2008 : Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-alpha and PGE2 ... Instead, TNF-alpha and PGE2 increased Stat1 serine phosphorylation and Stat4 tyrosine phosphorylation and activated expression of the NF-kappaB and Stat1 target gene IFN regulatory factor 1 (IRF1) , which contributes to IFN responses
Nizamutdinova et al., J Agric Food Chem 2009 : Moreover, pretreatment with a Jak/STAT inhibitor decreased TNF-alpha induced VCAM-1 expression and nuclear GATA-4, GATA-6, and IRF-1 levels
Drew et al., J Interferon Cytokine Res 1995 : We demonstrated here that TNF-alpha induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and IFN-gamma induced binding of IRF-1 to the adjacent interferon consensus sequence ( ICS )
Lopez-Ocejo et al., Biol Res 1995 : Results obtained showed that IRF-1 was highly inducible by IFN treatment, IFN-alpha, TNF-alpha and IRF-2 were weakly induced by IFN treatment, and IFN-beta was not inducible by priming the cells with recombinant human IFN-alpha 2b
Agresti et al., Eur J Neurosci 1998 : This transcriptional regulation of IRF-1 gene by IFN-gamma and TNF-alpha was confirmed at the mRNA level
Gupta et al., J Immunol 1998 : In contrast to induction of STATs by cytokines, the IRF-1 GAS binding complex activated by CD40, TNF-alpha , or EBV contains Rel proteins, specifically p50 and p65
Blanch et al., J Immunol 1999 : We previously reported that IFN-gamma and TNF-alpha induce production of the transcription factor IFN regulatory factor-1 (IRF-1) in HT-29 cells and that IRF-1 binds to an element in exon 1 of the PIGR gene ... We now report that levels of IRF-1 and pIgR mRNA are coordinately regulated in HT-29 cells by TNF-alpha , IFN-gamma, and IL-1beta