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PTEN — RPTOR

Text-mined interactions from Literome

Sherbakova et al., Mol Biol (Mosk) 2008 (Prostatic Neoplasms) : Transfection of PTEN into PTEN-deficient PC3 as well as rapamycin treatment caused the inhibition of PI3K/Akt/mTOR signaling and resulted in cell sensitization to the action of doxorubicin and vinblastine
Han et al., Clin Cancer Res 2009 (Chordoma) : Strikingly, expression of PTEN , a negative regulator of mTORC1 signaling, was not detected or significantly reduced in chordoma derived cell lines and primary tumors
Wang et al., Cancer Res 2012 (Disease Models, Animal...) : Here we describe a new genetically engineered mouse model of prostate cancer in which PI3K-Akt-mTOR signaling is activated by inducible disruption of PTEN , and extracellular signal regulated kinase 1/2 ( ERK1/2 ) MAPK signaling is activated by inducible expression of a BRAF ( V600E ) oncogene
Weston et al., J Neurosci 2012 (Synaptic Transmission) : We therefore performed an electrophysiological and morphological comparison of glutamatergic and GABAergic neurons in which mTOR signaling was either increased by loss of the repressor Pten or decreased by treatment with rapamycin
Tanwar et al., PLoS Genet 2012 (Adenoma...) : Loss of PTEN , an upstream regulator of mTORC1 signaling, along with Lkb1 deletion significantly increased tumor burden in uteri and induced tumorigenesis in the cervix and vagina