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BCL10 — IL2

Text-mined interactions from Literome

Lord et al., J Immunol 2000 : The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5
Quéméneur et al., J Immunol 2002 : Although it blocks IL-2 mediated proliferation, MPA does not inhibit cell survival and Bcl-x ( L ) up-regulation by IL-2 or other cytokines whose receptors share the common gamma-chain ( CD132 )
Ilangumaran et al., J Immunol 2003 (Lymphoproliferative Disorders) : However, IL-15 and IL-2 induce comparable levels of Bcl-2 and Bcl-x ( L ) in SOCS1-deficient and SOCS1-sufficient CD8+ T cells, suggesting that cytokine receptor signals required for inducing proliferation and cell survival signals are not identical
Zeng et al., J Biol Chem 2008 : Previous studies have demonstrated that Bcl10 ( B-cell leukemia/lymphoma 10 ) is essential for T cell receptor mediated NF-kappaB activation and subsequent proliferation and interleukin 2 (IL2) production ... When CD4+ and CD8+ T cells were divided based on expression levels of CD44, which distinguishes naïve cells ( CD44lo ) versus those that are antigen experienced ( CD44hi ), IL2 production by and proliferation of CD4+CD44lo naïve cells and both subpopulations of CD8+ T cells were clearly Bcl10 dependent , whereas these same functional properties of CD4+CD44hi T cells occurred largely independent of Bcl10
Chan et al., J Pathol 2010 (Lymphoma, Extranodal NK-T-Cell) : Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer lymphoma cells
Mueller et al., J Immunol 1996 : Differential regulation of bcl-2 and bcl-x by CD3, CD28, and the IL-2 receptor in cloned CD4+ helper T cells
Lord et al., J Immunol 1998 : The IL-2 receptor promotes proliferation, bcl-2 and bcl-x induction, but not cell viability through the adapter molecule Shc