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SNN — TNF
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Reese et al., J Pharmacol Exp Ther 2005
:
Protein kinase C epsilon regulates
tumor necrosis factor-alpha induced
stannin gene expression ... In this study, we investigated a signaling mechanism by which Snn gene expression is regulated by TMT and demonstrated that
TNFalpha stimulates
Snn gene expression in a protein kinase C epsilon dependent manner in HUVECs in response to TMT exposure ... This
TNFalpha induced
Snn gene expression is blocked when HUVECs were pretreated with bisindolylmaleimide I, an inhibitor of protein kinase C ( PKC ) ... Using isotype-specific siRNA against PKC, we further show that knockdown of PKC epsilon, but not PKC delta or PKC zeta, significantly blocked
TNFalpha induced
Snn gene expression
Billingsley et al., J Cell Biochem 2006
:
TNFalpha can
induce Snn mRNA expression in endothelial cells in a PKC-epsilon dependent manner
Reese et al., Gene Expr 2006
:
We have recently demonstrated in human umbilical vein endothelial cells ( HUVECs ) that
Snn gene expression is significantly
induced by
tumor necrosis factor-alpha (TNF-alpha) in a protein kinase C-epsilon ( PKC-epsilon ) -dependent manner ... In order to assess how
Snn may be
involved in
TNF-alpha signaling in HUVEC growth arrest, we performed microarray analysis of TNF-alpha stimulated HUVECs with and without Snn knockdown via siRNA