◀ Back to MAPK1
ITGAV — MAPK1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK1
→
Complex of ITGAV-ITGB3
(increases, ITGAV/ITGB3 Activity)
Bao et al., Mol Cell Biol 2002*
Evidence: Cell attachment to fibronectin through ITGAV.ITGB3 activated the phosphorylation of ERK-2 within 60 minutes. ERK-2 activation was detected even in the presence of dn Cdc42 or dn Rac1 after attachment to fibronectin, indicating that these integrin-induced signaling components are still activated by attachment when Cdc42 and Rac1 are blocked.
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OpenBEL Selventa BEL large corpus:
MAPK1
→
Complex of ITGAV-ITGB3
(increases, ITGAV/ITGB3 Activity, MAPK1 Activity)
Rüegg et al., Biochim Biophys Acta 2004*
Evidence: Activated ERK enters the nucleus to promote transcription [64]. The MAPK pathway is critically involved in controlling proliferation, survival, and migration of endothelial cells. Angiogenesis in the chorio-allantoid membrane (CAM) model requires two waves of ERK activation, the first one being dependent on FGF-2, and the second one on aVh3 integrin ligation [65].
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OpenBEL Selventa BEL large corpus:
MAPK1
→
Complex of ITGAV-ITGB3
(increases)
Bao et al., Mol Cell Biol 2002*
Evidence: Cell attachment to fibronectin through ITGAV.ITGB3 activated the phosphorylation of ERK-2 within 60 minutes. ERK-2 activation was detected even in the presence of dn Cdc42 or dn Rac1 after attachment to fibronectin, indicating that these integrin-induced signaling components are still activated by attachment when Cdc42 and Rac1 are blocked.
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NCI Pathway Database Integrins in angiogenesis:
Erk1-2 (MAPK3/MAPK1)
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alphav/beta3 Integrin/JAM-A complex (F11R-ITGAV-ITGB3)
(modification, collaborate)
Naik et al., J Cell Sci 2006
Evidence: mutant phenotype, assay
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NCI Pathway Database Integrins in angiogenesis:
alphav/beta3 Integrin/JAM-A complex (F11R-ITGAV-ITGB3)
→
Erk1-2-active (MAPK3/MAPK1)
(modification, activates)
Naik et al., J Cell Sci 2006
Evidence: mutant phenotype, assay
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NCI Pathway Database Integrins in angiogenesis:
Erk1-2 (MAPK3/MAPK1)
→
alphav/beta3 Integrin complex (ITGAV-ITGB3)
(modification, collaborate)
Naik et al., Blood 2003, Eliceiri et al., J Cell Biol 1998
Evidence: mutant phenotype, assay, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Roux et al., J Biol Chem 2005
(Edema) :
The inhibitory effect of IL-1beta on alpha ENaC expression was mediated by the activation of p38
MAPK in both rat and human ATII cells and was
independent of the activation of
alpha v beta6 integrin and transforming growth factor-beta
Vellon et al., Mol Carcinog 2006
(Breast Neoplasms...) :
Here, we have assessed the
role of the extracellular signal regulated kinase ( ERK1 ) /ERK2,
mitogen activated protein kinase ( MAPK ), and phospoinositide 3-kinase (PI-3'K) signaling pathways in the expression and function of
alpha(v)beta(3) integrin in breast cancer models