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FGFR1 — MYLIP

Text-mined interactions from Literome

Rio-Machin et al., Leukemia 2013 (Multiple Myeloma...) : We found that target genes of the most differentially expressed miRNAs are directly involved in the pathogenesis of MM ; specifically, the inhibition of hsa-miR-425 , hsa-miR-152 and hsa-miR-24, which are all downregulated in h-MM, leads to the overexpression of CCND1, TACC3, MAFB, FGFR3 and MYC, which are the also the oncogenes upregulated by the most frequent IgH chromosomal translocations occurring in nh-MM. Importantly, we showed that the downregulation of these specific miRNAs and the upregulation of their targets also occur simultaneously in primary cases of h-MM
Kim et al., Nat Med 2013 (Hypertension, Pulmonary...) : APLN deficiency in these cells led to increased expression of FGF2 and its receptor FGFR1 as a consequence of decreased expression of miR-424 and miR-503, which directly target FGF2 and FGFR1
Wen et al., Tumour Biol 2013 (Stomach Neoplasms) : miR-133b acts as a tumor suppressor and negatively regulates FGFR1 in gastric cancer ... In dual-luciferase reporter assay, miR-133b reduced the luciferase activity of Luc-FGFR1-wt , and mutation of miR-133b binding sites abolished the inhibitory effect of miR-133b ... In this study, we found that miR-133b reduced the protein but not the mRNA levels of endogenous FGFR1
Mor et al., Neurobiol Dis 2013 (Postmortem Changes) : We further found that miR-382 directly regulates the expression of two genes, FGFR1 and SPRY4, which are downregulated in both the cultured olfactory cells and LCM-OE derived from schizophrenia patients ... We further found that miR-382 directly regulates the expression of two genes, FGFR1 and SPRY4, which are downregulated in both the cultured olfactory cells and LCM-OE derived from schizophrenia patients