Gene interactions and pathways from curated databases and text-mining

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CXCR4 — IL1B

Text-mined interactions from Literome

Shirazi et al., J Hum Virol 1998 : Although treatment of PBMCs with interferon-alpha ( IFN-alpha ) and IFN-gamma led to a significant repression of CXCR4 gene expression, interleukin-1 beta (IL-1 beta) , IL-6, and tumor necrosis factor-alpha (TNF-alpha) had no significant effect on CXCR4 gene expression in PBMCs. IFN-alpha and IFN-gamma also inhibited CXCR4 gene expression in the promyelocytic cell line U937, and this inhibition led to a decrease in cell-cell fusion between U937 cells and HeLa-MAGI cells
Oh et al., J Immunol 2001 (Astrocytoma...) : The peak of CXCR4 expression in response to TNF-alpha and IL-1beta was 8 and 4 h, respectively
Schutyser et al., Eur Cytokine Netw 2007 (Anoxia...) : CXCR4 mRNA expression was not affected by VEGF, GM-CSF, IL-1beta or various basal membrane matrix components, but was significantly up-regulated after serum starvation and/or hypoxic treatment of the microvascular endothelial cells