Wang et al., J Biol Chem 2000
(Breast Neoplasms...) :
Moreover, ectopic expression of cyclin D1 and Cdk4 can stimulate the Brca1 promoter in an E2F dependent manner, and this is inhibited by coexpression of the p16(INK4a) cyclin dependent kinase inhibitor
Bindra et al., Cancer Biol Ther 2006
(Breast Neoplasms...) :
We have shown recently that the tumor microenvironmental stress of hypoxia induces an E2F dependent repression of BRCA1 in cancer cells