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IGF1R — IL6R

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of IGF1R-IL6R → IL6 (increases) Ishikawa et al., J Clin Exp Hematop 2006*
  Evidence: Accordingly, under the cellular context of the elevated expression of IL- 6Ra on myeloma cells, it is assumed that IL-6Ra molecules are located close to IGF-I receptors at lipid rafts, and IL-6 stimulation triggers the complex formation of IL-6Ra not only with gp130 but also with IGF-I receptors, leading to autophosphorylation of IGF-I receptor b and subsequent acti- vation of PI-3 kinase-Akt pathways (Fig. 4) 79 .

Text-mined interactions from Literome

Abroun et al., Blood 2004 (Multiple Myeloma) : The synergistic effects of highly expressed IL-6R alpha on IGF-I receptor mediated signals provide a novel insight into the Jak independent IL-6 signaling mechanism of receptor cross-talk in human myeloma cells
Ishikawa et al., J Clin Exp Hematop 2006 (Multiple Myeloma) : The synergistic effects of IL-6Ralpha on IGF-I receptor mediated signals provide a novel insight into a Jak independent IL-6 signaling mechanism of receptor cross talk in human myeloma cells