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DUSP9 — MAPK3
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK3
→
DUSP9
(directlyDecreases, DUSP9 Activity, MAPK3 Activity)
Evidence: The second subfamily comprises DUSP6, DUSP7 and DUSP9. They consist of 3 exons, are cytoplasmic in their subcellular localization and preferentially recognize ERK1 and ERK2 in vitro.
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BioCarta regulation of map kinase pathways through dual specificity phosphatases:
DSP (DUSP1/DUSP9/DUSP8/DUSP2/DUSP4/DUSP6)
→
MAPK (MAPK8/MAPK14/MAPK3)
(modification, activates)
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KEGG MAPK signaling pathway:
DUSP1/DUSP10/DUSP14/DUSP16/DUSP2/DUSP22/DUSP3/DUSP4/DUSP5/DUSP6/DUSP7/DUSP8/DUSP9
→
MAPK1/MAPK3
(protein-protein, inhibition)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Givant-Horwitz et al., Gynecol Oncol 2004
(MAP Kinase Signaling System...) :
The objective of the present study was to investigate the expression and clinical role of
dual-specificity phosphatases ( DUSP ) ,
inhibitors of
MAPK signaling, in ovarian cancer cells at this site
Kumabe et al., Microbiol Immunol 2010
:
Activation of
MAPK is negatively
regulated by
DUSP , which dephosphorylate the phosphothreonine and phosphotyrosine residues
Dickinson et al., J Biol Chem 2011
:
We conclude that
DUSP9/MKP-4 is a bona fide target of PKA signaling and that attenuation of DUSP9/MKP-4 function can
mediate cross-talk between the PKA pathway and
MAPK signaling through both ERK1/2 and p38a in vivo