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C1ORF228 — TLR2

Text-mined interactions from Literome

Kuwata et al., Immunity 2006 (Colitis...) : IkappaBNS-deficient macrophages and dendritic cells show increased TLR mediated expression of genes such as IL-6 and IL-12p40 , which are induced late after TLR stimulation
Bsibsi et al., Glia 2007 : Moreover, the CD14 triggered TLR2 mediated response in astrocytes lead to the production of CXCL8, IL-6, and IL12p40 , whereas typical TLR induced pro-inflammatory cytokines, like TNF-alpha and IL-1beta, were not produced at detectable levels
Zhou et al., J Leukoc Biol 2010 : Bone marrow derived macrophages ( BMDMs ) lacking significant SHP-1 activity display a profound defect in IL-12p40 synthesis in response to lipopolysaccharide, peptidoglycan, and synthetic TLR ligands, while producing normal amounts of other proinflammatory cytokines, such as TNFalpha and IL-6
Zhang et al., Cell Mol Immunol 2012 : Furthermore, Ras-guanine nucleotide releasing protein 1 ( RasGRP1 ) mediated the TLR2 induced ERK1/2 activation and inhibition of IL-12p40 production
Movita et al., J Leukoc Biol 2012 : Interestingly, despite expression of TLR mRNA on Kupffer cells, ligation of TLR4, TLR7/8 , and TLR9 resulted in a weak induction of IL-10, low or undetectable levels of IL-12p40 and TNF, and up-regulation of CD40 on the surface
Liu et al., Scand J Immunol 2013 : Our results demonstrate that not only TLR2 but also TLR4 and RP105 are involved in the response of macrophages to S. aureus, that TLR2, TLR4 and RP105 physically interact with each other during S. aureus infection, and that TLR2 , TLR4 and RP105 both cooperate and play unique roles in the production of inflammatory cytokines ( TNF-a, IL-12p40 and IL-10 ) and chemokine ( RANTES ) by macrophages after S. aureus infection
Koopman et al., Clin Exp Immunol 2013 : Both in humans and rhesus macaques, TLR-4 stimulation induced IL-12p40 expression in mDC and monocytes, but not in pDC