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CXCR4 — IRF6

Text-mined interactions from Literome

Juffermans et al., J Infect Dis 2000 : Thalidomide produced a dose dependent inhibition of lipopolysaccharide (LPS) induced up-regulation of CXCR4 and CCR5 in vitro
Juffermans et al., J Infect Dis 2002 (Endotoxemia...) : To test the hypothesis that an LPS effect on CXC chemokine receptor 4 (CXCR4) and CC chemokine receptor 5 (CCR5), known coreceptors for HIV, contributes to this effect, 8 healthy men were intravenously injected with Escherichia coli LPS ( 4 ng/kg ), and monocyte CXCR4 and CCR5 expression was monitored by fluorescence activated cell sorter analysis ... In whole blood in vitro, not only LPS but also lipoarabinomannan ( a cell wall component of Mycobacterium tuberculosis ) and lipoteichoic acid ( a cell wall component of Staphylococcus aureus ) down-regulated the expression of CXCR4 and CCR5 on monocytes ( all P < .05 )
Cruz et al., Arch Dermatol Res 2005 (Dermatitis, Allergic Contact) : Lipopolysaccharide (LPS) , which induces the maturation of DC, also reduced surface CCR6 and CXCR4 expression
Li et al., Blood 2007 (MAP Kinase Signaling System) : Specific inhibition of ERK during CB DC maturation enhanced LPS induced up-regulation of CCR7 and CXCR4 on CB DCs and their chemotaxis toward CCL19 and CXCL12, to a level similar to that of mature AB DCs ... Overall, monocyte derived CB DCs responded to LPS with stronger and sustained ERK activation, which negatively correlated with LPS induced up-regulation of CCR7 and CXCR4 on CB DCs and their migratory responses
Kim et al., Int J Hematol 2007 : We show that LPS reduces CXCR4 surface expression in a dose- and time dependent manner in neutrophils and monocytes, but not in lymphocytes
Gong et al., J Endod 2010 (Inflammation) : All concentrations of LPS inhibited SDF-1alpha production except that 1 microg/mL LPS increased the expression of CXCR4
Cheng et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011 : Further study found that LPS did not affect the expression level of CXCR4 on CD34 ( + ) cells, but could inhibit the spontaneous migration ability of CD34 ( + ) cells