Kishiwada et al., Journal of thrombosis and haemostasis : JTH 2008
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However, it is not fully understood how lipopolysaccharide (LPS) and IL-6 affect the plasma C4BP antigen level and C4BPalpha and C4BPbeta expression in hepatocytes ... To assess the effect of LPS and IL-6 on plasma C4BP , PS-C4BP complex levels, PS activity, and C4BP expression by rat liver in vivo and on C4BP expression by isolated rat hepatocytes in vitro
Hayashi et al., Gastroenterology research and practice 2010
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These data suggest that the LPS induced decrease in PS expression in hepatocytes and SECs and LPS induced decrease in C4BP expression in hepatocytes are mediated by MEK/ERK signaling and NF?B activation and that membrane bound CD14 and TLR-4 are involved in this mechanism