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IRF6 — PI3

Text-mined interactions from Literome

Monick et al., J Immunol 2000 : We found that LPS activates PI 3-kinase and causes the formation of a PKC zeta/PI 3-kinase dependent kinase complex
Monick et al., J Immunol 2001 : Consistent with this, we found that LPS caused an increase in the amounts of PI 3-kinase dependent nuclear beta-catenin in human alveolar macrophages and expression of genes that require nuclear beta-catenin for their activation
Monick et al., J Immunol 2001 : In human alveolar macrophages, we found that LPS activates PI 3-kinase and its downstream effector, Akt ... Because ceramide exposure induces apoptosis in other cell types and the PI 3-kinase pathway is known to inhibit apoptosis, we determined the relationship between LPS induced ceramide and PI 3-kinase activation in alveolar macrophages ... When we blocked LPS induced ceramide with the inhibitor D609, we blocked LPS induced PI 3-kinase and Akt activation
Ojaniemi et al., Eur J Immunol 2003 : In this study, the consequences of LPS induced PI 3-kinase activation on cytokine and chemokine expression and the intracellular mechanisms of inflammatory activation were examined in mouse macrophages
Arndt et al., J Biol Chem 2004 : In addition, LPS stimulation of non suspended neutrophils activates Syk and phosphatidylinositol 3-kinase (PI3K)
Jhun et al., Biochem Biophys Res Commun 2004 : Finally, we observed that AICAR inhibited LPS induced activation of PI 3-kinase and Akt, whereas it had no effect on the activation of p38 and ERK1/2
Lee et al., Neurosci Lett 2006 (Encephalitis...) : Adenosine inhibited LPS induced phosphatidylinositol (PI) 3-kinase activation and Akt phosphorylation, whereas it had no effect on the phosphorylation of p38 and ERK1/2
Peck et al., Shock 2006 : We hypothesized that LPS or S. aureus induced tolerance and priming responses to each other are PI3 kinase pathway dependent
Liu et al., Mol Immunol 2007 : Further studies show that the triptolide mediated inhibitory effects of LPS induced activation of phosphatidylinositol-3 kinase (PI3-K)/Akt and nuclear NF-kappaB activation are involved in down-regulation of COX-2 and CCR7 expression resulting in impaired migration to secondary lymphoid organs of DC
Poulaki et al., FASEB J 2007 (Leukostasis...) : 17-AAG treatment significantly suppressed the LPS induced increase in retinal leukocyte adhesion ; vascular leakage ; NF-kappaB, HIF-1alpha, p38, and PI-3K activity ; and VEGF, TNF-alpha, and IL-1beta levels
Orellana et al., Pediatr Res 2008 (Disease Models, Animal...) : In liver, activation of the insulin receptor, IRS-1, and PI 3-kinase were not affected by LPS , but p42 MAPK phosphorylation was increased
Lai et al., J Agric Food Chem 2009 : We also found that rosmanol suppressed LPS induced phosphorylation of ERK1/2, p38 mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling
Check et al., Mol Immunol 2010 : The hypothesis is that LPS induced src kinase and PI3 kinase (PI3K) facilitates the activation of p47(phox), the regulatory subunit of NADPH oxidase ... Importantly, these data suggest that LPS induced src kinase activation is critical for PI3 kinase activation as well as TLR4 phosphorylation and is dependent upon LPS induced increase in intracellular calcium
Fortin et al., Eur J Immunol 2011 : Finally, we show that in LPS- and TNF activated neutrophils, PI3K acts downstream of the kinases p38 MAPK and TAK1
Tsai et al., Int Immunopharmacol 2012 : In the present study, we demonstrated the differential effects of two phosphatidylinositol 3-kinase (PI3K) inhibitors, LY294002 and wortmannin, on lipopolysaccharide- (LPS) and interferon ( IFN ) -?-induced NO production in a glomerular mesangial cell line, MES-13 cells
Zhao et al., FEBS Lett 2012 : In this report, we analyzed the effect of two known phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 and wortmannin on LPS- and poly ( I:C ) -induced IFN-ß production in peritoneal macrophages
Maitra et al., J Immunol 2012 : Unlike high-dose LPS, low-dose LPS does not induce robust activation of NF-?B, MAPKs, PI3K , or anti-inflammatory mediators
Lee et al., J Cell Biochem 2013 : NaHS blocked nicotine and LPS induced activation of p38, ERK, MKP-1, PI3K , PKC, and PKC isoenzymes, and NF-?B
Herrera-Velit et al., J Immunol 1996 (Lymphoma, Large B-Cell, Diffuse) : To examine whether LPS activates PI 3-kinase , freshly isolated human, peripheral blood monocytes were labeled in vitro with [ 32P ] orthophosphate, and inositol phospholipids were detected after extraction and separation of lipids by TLC
Salh et al., J Immunol 1998 : In this study we demonstrate that LPS induced a fivefold activation of p70 S6 kinase and a twofold stimulation of PI 3-kinase