◀ Back to C1QB

C1QB — SELP

Text-mined interactions from Literome

Skoglund et al., Immunobiology 2010 : C1q induces a rapid up-regulation of P-selectin and modulates collagen- and collagen related peptide triggered activation in human platelets ... Using flow cytometry, we found that C1q dose-dependently triggered a rapid but moderate and transient up-regulation of P-selectin already within 5s of C1q exposure ... Stimulation with C1q did not change the cytosolic calcium-levels, as measured with the fluorescent ratiometric probe Fura-2, however, a protein kinase C inhibitor ( GF109203x ) blocked the C1q induced P-selectin expression ... In summary, C1q induces a moderate rapid platelet P-selectin expression, modulates subsequent collagen and collagen related peptide stimulation of platelets, and inhibits the formation of platelet-neutrophil aggregates
Skoglund et al., Immunol Lett 2012 : C1q regulates collagen dependent production of reactive oxygen species, aggregation and levels of soluble P-selectin in whole blood