Inoue et al., Life Sci 2000
:
All HMG-CoA reductase inhibitors significantly reduced interleukin-1beta and -6 mRNA expression and their protein levels in the culture medium, and also inhibited cyclooxygenase-2 mRNA expression and their protein levels
Chen et al., Exp Cell Res 2004
(MAP Kinase Signaling System) :
HMG-CoA reductase inhibitors induce COX-2 gene expression in murine macrophages : role of MAPK cascades and promoter elements for CREB and C/EBPbeta