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LYN — PTPN11
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
LYN
→
PTPN11
(reaction)
Schneider et al., Biochem Biophys Res Commun 2000*, Tauchi et al., J Biol Chem 1994, Miyatake et al., Biochem Biophys Res Commun 1998
-
Reactome Reaction:
LYN
→
PTPN11
(indirect_complex)
Schneider et al., Biochem Biophys Res Commun 2000*, Tauchi et al., J Biol Chem 1994, Miyatake et al., Biochem Biophys Res Commun 1998
Text-mined interactions from Literome
Kusano et al., Endothelium : journal of endothelial cell research 2008
:
To see if tyrosine kinases other than Src are also capable of phosphorylating PZR, the authors cotransfected HEK293 cells with PZR and one of several tyrosine kinases and found that c-Src, c-Fyn,
c-Lyn , Csk, and c-Abl, but not c-Fes, phosphorylated PZR and
increased PZR/SHP-2 interaction
Adachi et al., Oncogene 1997
:
In COS-7 cells, co-expression of SHP-2 with
Lyn resulted in increased tyrosine phosphorylation levels of
SHP-2 , whereas co-expression of SHP-2 with Fyn failed to alter the levels significantly ... Considering that Lyn and Fyn are major Src-family PTKs expressed in BAF-B03 cells, our data suggest that
Lyn may be principally
responsible for the tyrosine phosphorylation of
SHP-2 in F7 cells