Gene interactions and pathways from curated databases and text-mining

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FGF4 — IL6

Text-mined interactions from Literome

Fima et al., Eur Cytokine Netw 1999 (MAP Kinase Signaling System) : The effects of FGF and PDGF on IL-6 production were blocked in the presence of PKC inhibitors
Sandell et al., Osteoarthritis Cartilage 2008 (Arthritis) : In the presence of IL-1beta, FGF-18 increased expression of ADAMTS-4, aggrecan, BMP-2, COL2A1, CCL3, CCL4, CCL20, CXCL1, CXCL3, CXCL6, IL-1beta, IL-6 , and IL-8 and decreased ADAMTS-5, MMP-13, CCL2, and CCL8
Palasz et al., Theriogenology 2008 : Expression of Fgf-4 and Gsta4 in the in vitro embryos was lower in PBS than in the remaining three buffers ( P < 0.05 ) and the level of expression of the Il6 gene was not affected by any buffer tested but was lower in in vitro than in in vivo derived embryos
Guerne et al., J Immunol 1990 : fibroblast growth factor , insulin growth factor-1 and 2, platelet growth factor or insulin, was able to significantly increase IL-6 synthesis
Chandrasekhar et al., J Cell Physiol 1989 : Induction of interleukin-1 receptors on chondrocytes by fibroblast growth factor : a possible mechanism for modulation of interleukin-1 activity
Iwamoto et al., Immunol Lett 1989 : Furthermore, interleukin 1 (IL-1) suppressed by 50-60 % the incorporation of [ 3H ] thymidine into DNA in high density chondrocyte cultures on plastic dishes in the presence of 10 % serum or fibroblast growth factor , although it increased twofold this incorporation in 0.3 % serum alone
Norioka et al., Jpn J Cancer Res 1994 (Neovascularization, Pathologic) : Interaction of interleukin-1 and interferon-gamma on fibroblast growth factor induced angiogenesis
Dooley et al., J Cell Physiol 1995 : Basic FGF did not reduce the levels of interleukin-6 (IL-6) , GM-CSF, or G-CSF released by steady state or IL-1 stimulated stroma
Berardi et al., Blood 1995 : To address the direct effects of FGF, we investigated whether FGF induced production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha, IL-6 , granulocyte colony stimulating factor, or granulocyte-macrophage colony stimulating factor by two types of accessory cells, bone marrow ( BM ) fibroblasts and macrophages