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ICAM1 — ITIH4

Text-mined interactions from Literome

Ren et al., Lab Invest 2002 : We found, for the first time, that both soluble and membrane bound gp120 could significantly increase the expression of human endothelial intercellular adhesion molecule-1 ( ICAM-1 ) at both mRNA and protein levels, but not vascular cell adhesion molecule-1 and E-selectin ... The specificity of gp120 mediated response was demonstrated by blocking experiments using a specific monoclonal antibody against gp120, which successfully abolished the gp120 mediated increase of ICAM-1 expression ... These findings suggest that HIV-1 gp120 mediated endothelial ICAM-1 expression could be one of the important mechanisms of HIV-1 pathogenesis
Stins et al., Lab Invest 2003 : Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120 : role of CD4 and chemokine coreceptors ... In the present study, we found that gp120 derived from both X4 and R5 HIV-1 induced increased expression of ICAM-1 on HBMEC, but the degree of this up-regulation differed among the various HBMEC isolates ... Anti-CD4 antibodies inhibited the increase in ICAM-1 expression mediated by gp120 derived from X4 and R5 HIV-1, whereas antibodies against chemokine receptors displayed a differential inhibition depending on the source of gp120 ... Both X4 and R5 gp120 induced ICAM-1 expression was sensitive to pertussis toxin and involved the nuclear factor-kB pathway
Shrikant et al., J Immunol 1996 (Astrocytoma) : Our results indicate that gp120 enhances ICAM-1 gene expression in primary rat astrocytes, primary human astrocytes, a human astroglioma cell line CRT, and primary rat microglia ... The signal transduction events involved in gp120 mediated enhancement of ICAM-1 appear to involve activation of both protein kinase C and tyrosine kinase, because inhibitors of protein kinase C and tyrosine kinase abrogate gp120 mediated ICAM-1 expression in both astrocytes and microglia ... We also demonstrate that gp120 mediated ICAM-1 expression has functional significance, as it enhances the ability of monocytic cells to bind to gp120 stimulated human astrocytes in an ICAM-1/beta 2 integrin dependent fashion