Op De Beeck et al., J Virol 2001
:
They also suggest that induction of p21 ( cip1 ) by the viral protein NS1 arrests cells in G ( 2 ) through inhibition of cyclin A-dependent kinase activity
Morita et al., J Virol 2003
(Parvoviridae Infections) :
Furthermore, NS1 expression significantly increased p21/WAF1 expression, a cyclin dependent kinase inhibitor that induces G ( 1 ) arrest
Nakashima et al., Virology 2004
:
The expression of human Parvovirus B19 nonstructural protein 1 (NS1) induces cell cycle arrest at the G1 phase and is accompanied by increased expression of the cyclin dependent kinase inhibitor, p21/WAF1 ... Up-regulation of p21/WAF1 by wild-type NS1 but not an NS1 mutant deleted of its NTP binding motif was observed