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BAX — TAT
Text-mined interactions from Literome
Macho et al., Oncogene 1999
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
These pre-apoptotic events were associated with the cleavage of the caspase-3, while the expression of Bcl-2, Bcl-XL and
Bax proteins was not
affected by the presence of
Tat
Guan et al., Neuroscience 2006
(Brain Injuries...) :
At the same time, through inhibiting phosphorylation of Bcl-2 ( a cytosolic target of JNK ) and the release of Bax from Bcl-2/Bax dimers,
Tat-JBD attenuated
Bax translocation to mitochondria and the release of cytochrome c induced by ischemia/reperfusion
Jajoo et al., Neuroscience 2008
:
Functionally, PTX-B reduced
Tat induced
Bax and caspase-3 proteins and reduced cell apoptosis