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CCND1 — CNTN2

Text-mined interactions from Literome

Mori et al., Int J Cancer 2002 (Leukemia, T-Cell) : Compared to uninfected cells, higher expression levels of cyclin D1 and D2 mRNA were detected in HTLV-I infected T-cell lines, which were at least in part mediated by the viral transforming protein Tax since Tax activated both cyclin D1 and D2 promoters in the human T-cell line Jurkat ... Inhibitors of NF-kappaB ( dominant negative IkappaBs mutants ) suppressed Tax dependent activation of cyclin D1 and D2 promoters, indicating that Tax induced activation was mediated by NF-kappaB
Kim et al., Oncogene 2010 (Cell Transformation, Viral) : Together, our findings support a model in which Tax induced accumulation of cyclin D1 shortens the G1 phase of the cell cycle, promotes mitotic replication of the virus, and drives selection and expansion of malignant T-cells