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ARF6 — MAPK3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Arf6 downstream pathway:
Erk1-2 (MAPK3/MAPK1)
→
ARF6/GTP complex (ARF6)
(modification, collaborate)
Tague et al., Proc Natl Acad Sci U S A 2004*, Li et al., Cancer Res 2006*, Tushir et al., EMBO J 2007
Evidence: genetic interaction, assay
-
NCI Pathway Database Arf6 downstream pathway:
ARF6/GTP complex (ARF6)
→
Erk1-2-active (MAPK3/MAPK1)
(modification, activates)
Tague et al., Proc Natl Acad Sci U S A 2004*, Li et al., Cancer Res 2006*, Tushir et al., EMBO J 2007
Evidence: genetic interaction, assay
Text-mined interactions from Literome
Tzachanis et al., J Immunol 2003
:
Forced expression of
ARF6-GTP in primary human T cells
inhibited extracellular signal regulated kinase1/2 activation and proliferative responses
Daher et al., Cell Signal 2008
:
In non stimulated cells, depletion of
ARF6 leads to increased FAK and
Erk1/2 phosphorylation, similar to what is observed in ET-1 treated cells
Li et al., Cancer 2009
(Glioblastoma) :
This stimulation was caused by increased transcription of
ARF6 and by
activation of the
MEK/extracellular signal regulated kinase 1 and 2 ( ERK1/2 ) and PI3K signaling pathways