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:
Both the unmodified and the partially purified His tagged p94 bound calcium with high affinity, and their autolytic activity required Ca2+ Yamaguchi et al., J Am Soc Nephrol 2006
(Polycystic Kidney Diseases...) :
Elevation of intracellular Ca2+ levels in ADPKD cells increased Akt activity and blocked cAMP dependent B-Raf and ERK activation