◀ Back to STAT3
STAT3 — STAT4
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT3 (dimer ) complex (STAT3)
→
STAT4 (dimer) complex (STAT4)
(transcription, activates)
Szabo et al., Science 2002, Kusaba et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT4 (STAT4)
→
STAT3 (STAT3)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
STAT4 (STAT4)
→
STAT3/STAT4 complex (STAT3-STAT4)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (STAT3)
→
STAT3/STAT4 complex (STAT3-STAT4)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
Evidence: assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Li et al., J Immunol 2006
(Encephalomyelitis, Autoimmune, Experimental) :
Indeed, in the present study we found that bone marrow derived DCs transduced with SOCS-3 significantly inhibited IL-12 induced activation of
Stat4 and IL-23 induced
activation of
Stat3
Wang et al., J Mol Med (Berl) 2013
:
These effects, in turn, may be mediated by EGCG induced downregulation of transducers p-STAT1 and
p-STAT4 for Th1, and
p-STAT3 for Th17. EGCG induced change in Th17/Treg balance may be
mediated by its inhibition of IL-6 signaling because EGCG inhibited soluble IL-6R, membrane gp130, and IL-6 induced phosphorylation of STAT3