Gene interactions and pathways from curated databases and text-mining

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IL6 — RAF1

Text-mined interactions from Literome

Jirakulaporn et al., J Biol Chem 2004 (MAP Kinase Signaling System) : We also show that the C. elegans protein CDF-1 and its mammalian homologue ZnT-1 bind to the amino-terminal regulatory portion of Raf-1 and promote the biological and enzymatic activity of Raf-1
Nakajima et al., Mol Cell Biol 1993 (Carcinoma, Hepatocellular...) : Despite the similarity in the structure between the JRE-IL6 element and the polyomavirus enhancer PyPEA3, composed of an EBS and an AP1 binding site and known to be activated by a variety of oncogene signals, JRE-IL6 could not be activated by activated Ha-Ras, Raf-1 , or 12-O-tetradecanoylphorbol-13-acetate