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CAV3 — EGFR

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CAV3 — EGFR (direct interaction, pull down) Couet et al., J Biol Chem 1997*
• IRef Biogrid Interaction: CAV3 — EGFR (physical association, affinity chromatography technology) Couet et al., J Biol Chem 1997*
• IRef Hprd Interaction: CAV3 — EGFR (in vivo) Couet et al., J Biol Chem 1997*
• IRef Hprd Interaction: CAV3 — EGFR (in vitro) Couet et al., J Biol Chem 1997*
• IRef Ophid Interaction: CAV3 — EGFR (aggregation, confirmational text mining) Couet et al., J Biol Chem 1997*
• IRef Ophid Interaction: CAV3 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Liu et al., Kidney Int 2005 : Depletion of caveolin-1 also significantly reduced the ouabain induced accumulation of Na/K-ATPase alpha-1 subunit, EGFR , Src, and MAPKs in clathrin-coat vesicles, as well as early and late endosomes
Kim et al., Exp Mol Pathol 2006 (Colorectal Neoplasms) : In conclusion, caveolin-1 is more expressed in cancer tissues than normal colon and related with Akt-1, not with EGFR expression in colorectal cancer tissues, which suggests that signaling for caveolin-1 affects Akt-1 activation, but this reaction is not initiated by EGFR stimulation in colon cancer
Gu et al., Zhonghua Zhong Liu Za Zhi 2007 (Carcinoma, Squamous Cell...) : EGFR was found to colocalize with caveolin-1 in transfected cells by confocal laser scanning microscopy and Western blotting results showed that overexpression of caveolin-1 reduced the phosphorylation of EGFR and Erkl/2
Wang et al., Cancer Res 2007 (Carcinoma, Squamous Cell) : Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1 , and ganglioside
Tencer et al., Anticancer Res 2008 : Our findings indicate that up-regulation of caveolin-1 by rosiglitazone requires superoxide formation and the activation of Src, EGFR , and the Mek1-Erk1/2 and p38 MAP kinase pathways
Dittmann et al., Molecular cancer 2008 : Inhibition of EGFR by the antibody Erbitux resulted in a strong accumulation of caveolin/EGFR complexes within the cytoplasm, which could not be further increased by irradiation
Thomas et al., Breast Cancer Res Treat 2010 (Breast Neoplasms) : Recombinant expression of caveolin-1 in TAM-R cells did not affect EGFR/ERK activity, potentially due to mislocalisation of caveolin-1 through hyperactivation of the mTOR pathway or altered caveolin-1 phosphorylation
Agelaki et al., Cancer Biol Ther 2009 (Adenocarcinoma...) : In this report we investigated the role of caveolin-1 overexpression on EGFR signaling in MCF-7 breast cancer cell line
Chen et al., Mol Cell Biol 2010 : Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator activated receptor gamma dependent caveolin-1 expression
Zuo et al., Breast Cancer Res 2010 (Breast Neoplasms...) : To define the potential inter-mediate steps between mPRalpha and PI3K, we demonstrated that mPRalpha, caveolin-1 (Cav-1), and epidermal growth factor receptor (EGFR) are colocalized in the membrane of caveolar vesicle and the P4-repressed EMT in MB468 cells can be blocked by EGFR inhibitor ( AG1478 ) and PI3K inhibitor ( wortmannin )