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CD4 — TLR2
Text-mined interactions from Literome
Gelman et al., J Immunol 2004
:
APC
TLR engagement indirectly
enhances activated
CD4 ( + ) T cell proliferation, differentiation, and survival by promoting the up-regulation of costimulatory molecules and the secretion of proinflammatory cytokines
Castellino et al., J Immunol 2007
:
Together, these findings support a model of CD8 ( + ) T cell memory cell differentiation involving the delivery of key signals early in the priming process based on chemokine guided attraction of naive CD8 ( + ) T cells to sites of Ag-driven interactions between
TLR activated dendritic cells and
CD4 ( + ) T cells
Tunheim et al., Vaccine 2007
:
The results show that
TLR2 and CD14 are efficient
targets for delivery of antigen to APC for stimulation of HLA class II-restricted
CD4 ( + ) T cells
Vasilevsky et al., Eur J Immunol 2008
:
These data are the first to demonstrate a major
role for B-cell and
CD4 ( + ) T-cell expression of
TLR2 for eliciting an anti-bacterial humoral immune response
Chen et al., J Infect Dis 2009
(Tuberculosis, Pleural...) :
Our results indicate that
CD4 ( + ) T cells from the pleural fluid and peripheral blood of patients with tuberculosis show significantly
increased TLR2 expression, compared with those from healthy donors
Wang et al., Eur J Immunol 2009
(Schistosomiasis japonica) :
CD4+CD25+ Treg induction by an HSP60 derived peptide SJMHE1 from Schistosoma japonicum is
TLR2 dependent ... Furthermore, our data support a
role for
TLR2 in SJMHE1 mediated
CD4 ( + ) CD25 ( + ) Treg induction
Piconi et al., AIDS 2010
(HIV Infections) :
Activated T cells ( Ki67 ( + ) ), Treg lymphocytes (
CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V,
activation of caspases 8 and 9,
Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed ... Activated T cells ( Ki67 ( + ) ), Treg lymphocytes (
CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V,
activation of caspases 8 and 9,
Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Ather et al., J Immunol 2011
(Disease Models, Animal...) :
CD4 ( + ) T cells polyclonally stimulated in the presence of conditioned media from SAA exposed DCs produced IL-17, and the capacity of polyclonally stimulated splenocytes to secrete IL-17 is
dependent upon IL-1,
TLR2 , and the NLRP3 inflammasome
Karrich et al., Blood 2013
:
We demonstrate that GrB induction was, in part, responsible for IL-21 mediated downmodulation of
CD4 ( + ) T-cell proliferation
induced by
TLR preactivated pDCs