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CDH1 — MYC
Text-mined interactions from Literome
Liu et al., Am J Physiol Cell Physiol 2009
:
The current study was performed to determine whether polyamines
induce E-cadherin expression through the transcription factor
c-Myc and whether polyamine regulated E-cadherin plays a role in maintenance of the epithelial barrier integrity ... Experiments using different E-cadherin promoter mutants revealed that
induction of
E-cadherin transcription by
c-Myc was mediated through the E-Pal box located at the proximal region of the E-cadherin promoter
Dai et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012
(Carcinoma, Squamous Cell...) :
E-cadherin promoter activity in
response to
Myc-Twist1 overexpression was measured by the dual luciferase reporter assay system
Liu et al., Cell Biol Int 2013
:
c-Myc suppressed
E-cadherin through miR-9 at the post-transcriptional level ...
E-cadherin expression is
repressed by
MYC through a post-transcriptional mechanism, but the exact mechanism remains elusive ... Overexpressed
c-Myc led to an EMT-like conversion in the T-REx-293 cells and
resulted in a significant decrease in
E-cadherin and an increase in Vimentin ... Thus
c-Myc represses
E-cadherin at the post-transcriptional level through miR-9
Batsché et al., Mol Cell Biol 1998
:
RB and
c-Myc activate expression of the
E-cadherin gene in epithelial cells through interaction with transcription factor AP-2 ... Here we show that both RB and
c-Myc specifically
activate transcription of the
E-cadherin promoter in epithelial cells but not in NIH 3T3 mesenchymal cells