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IGFBP1 — TGFB1
Text-mined interactions from Literome
Voci et al., Eur J Endocrinol 1999
:
Our results demonstrate that TGF-alpha and
TGF-beta1 significantly
stimulate IGF-I and
IGFBP secretion by cultured hepatocytes but no change in the abundance of IGF-I and IGFBP mRNAs was observed with respect to controls
Dahlfors et al., Endocrinology 2000
:
Transforming growth factor-beta1 inhibited IGFBP-3 ( P < 0.01 ),
IGFBP-4 ( P < 0.01 ), and IGF-I mRNA expression, whereas at the protein level only IGFBP-3 was significantly decreased ... In conclusion, vascular endothelial growth factor and
transforming growth factor-beta1 regulate
IGFBP expression in bovine aortic endothelial cells
Pereira et al., Am J Physiol Endocrinol Metab 2000
:
Parathyroid hormone decreased, whereas
transforming growth factor-beta and, to a lesser extent, bone morphogenetic protein 2
increased CTGF/IGFBP-rP2 mRNA levels, but other hormones and growth factors had no effect
Kuemmerle et al., Am J Physiol Gastrointest Liver Physiol 2004
:
Two mechanisms for this effect have been identified
: IGFBP-3 can directly
activate transforming growth factor-beta ( TGF-beta ) receptors or it can undergo direct nuclear translocation