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IRS1 — VEGFA

Text-mined interactions from Literome

Senthil et al., Biochem J 2002 : VEGF augmented tyrosine phosphorylation of IRS-1 in kidney epithelial cells and rat heart endothelial cells in a time dependent manner ... In the epithelial cells, association of IRS-1 with type 2 VEGF receptor was promoted by VEGF ... VEGF also increased association of IRS-1 with the p85 regulatory subunit of phosphoinositide 3-kinase ( PI 3-kinase ), and PI 3-kinase activity in IRS-1 immunoprecipitates was increased in VEGF treated cells
Hos et al., Invest Ophthalmol Vis Sci 2011 : In macrophages, VEGF-A expression levels were also inhibited by IRS-1 blockade
Maeno et al., J Biol Chem 2012 (Metabolic Diseases) : Thr-86 of p85/PI3K was identified to be phosphorylated by PKC activation and confirmed to affect IRS1 mediated activation of Akt/eNOS by insulin and VEGF using a deletion mutant of the Thr-86 region of p85/PI3K
Yin et al., Biochim Biophys Acta 2013 (Cell Transformation, Neoplastic...) : Forced expression of N-RAS and IRS1 restored VEGF expression via transcriptional activation