◀ Back to FAS

FADD — FAS

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CASP8 → Complex of CASP8-FADD-FAS (directlyIncreases, CASP8/FADD/FAS Activity)
  Evidence: a dimeric Smac/DIABLO molecule is required for binding to BIR2, but not to BIR3, which indicates significant differences in the affinity or mechanism by which Smac/DIABLO binds to these domains Figure 5: Association of IAPs with signalling complexes.
• OpenBEL Selventa BEL large corpus: FADD → Complex of EGFR-FAS (increases, EGFR/FAS Activity, FADD Translocation) Reinehr et al., J Biol Chem 2005*
  Evidence: Activated Yes rapidly associated with the epidermal growth factor receptor (EGFR), which became phosphorylated at Tyr845 and Tyr1173 but not at Tyr1045. Activated EGFR then triggered an AG1478-sensitive CD95-tyrosine phosphorylation, which was a signal for membrane targeting of the EGFR/CD95 complex, subsequent recruitment of Fas-associated death domain and caspase 8, and apoptosis induction. All of these events were significantly blunted by inhibitors of sphingomyelinase, PKCzeta, NADPH oxidase...
• OpenBEL Selventa BEL large corpus: FADD → Complex of FAS-FASLG (increases)
  Evidence: the classical induction of AICD is mediated via CD95, ligation of CD95 by CD95L leads to the recruitment of adapter proteins such as FADD, resulting in the activation of caspase 8, which in turn activates downstream caspases, including caspase 3, 6 and 7, and initates apoptosis independently of the apoptosome, although cytochrome C release and apoptosome activation are required for efficient cell death
• BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG) → FAF1 (modification, collaborate)
• BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG) → FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) (modification, collaborate)
  
• BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG) → PTPN13 (modification, collaborate)
• BioCarta fas signaling pathway (cd95): FAF1 → FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG) → Caspase 8/Caspase 8/Caspase 8/Caspase 8 complex (CASP8) (modification, activates)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG) → I-FLICE (CFLAR) (modification, activates)
• BioCarta fas signaling pathway (cd95): I-FLICE/RIP2 complex (CFLAR-RIPK2) → FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) (modification, activates)
  
• BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10 complex (FAS-DAXX-FADD-CASP10) → FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG) (modification, collaborate)
  
• BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10 complex (FAS-DAXX-FADD-CASP10) → TNFSF6 (FASLG) (modification, collaborate)
• BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG) → TNFSF6 (FASLG) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNFSF6 (FASLG) → FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNFSF6 (FASLG) → FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8) → FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG) (modification, collaborate)
  
• BioCarta fas signaling pathway (cd95): FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) → Caspase 7 (CASP7) (modification, activates)
• BioCarta fas signaling pathway (cd95): FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) → Caspase 7 (active) (CASP7) (modification, activates)
  
• BioCarta fas signaling pathway (cd95): FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) → JNKK1 (MAP2K4) (modification, activates)
• KEGG Apoptosis: FAS → FADD (protein-protein, activation)
• KEGG Alzheimer's disease: FAS/TNFRSF1A → FADD (protein-protein, activation)
• KEGG Chagas disease (American trypanosomiasis): FAS → FADD (protein-protein, activation)
• KEGG Pathways in cancer: FAS → FADD (protein-protein, activation)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, activates)
  Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10) → Caspase 10 (tetramer)/FADD/FADD complex (CASP10-FADD) (modification, collaborate)
  Kischkel et al., J Biol Chem 2001*, Wang et al., Proc Natl Acad Sci U S A 2001, Vincenz et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Kischkel et al., J Biol Chem 2001*, Wang et al., Proc Natl Acad Sci U S A 2001, Vincenz et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 10 (tetramer)/FADD/FADD complex (CASP10-FADD) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Kischkel et al., J Biol Chem 2001*, Wang et al., Proc Natl Acad Sci U S A 2001, Vincenz et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Caspase Cascade in Apoptosis: sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR) → Caspase 10 (CASP10) (modification, collaborate) Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR) → c-FLIP (CFLAR) (modification, collaborate) Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR) → FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10) (modification, collaborate)
  Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR) → Caspase 10 p12 (CASP10) (modification, collaborate) Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR) → c-FLIPL p12 (CFLAR) (modification, collaborate) Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 10 (CASP10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 10 (CASP10) → FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10) (modification, collaborate)
  Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: c-FLIP (CFLAR) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: c-FLIP (CFLAR) → FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10) (modification, collaborate)
  Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) → FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10) (modification, collaborate)
  Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) → Caspase 10 p12 (CASP10) (modification, collaborate) Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) → c-FLIPL p12 (CFLAR) (modification, collaborate) Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10) → Caspase 10 p12 (CASP10) (modification, collaborate) Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10) → c-FLIPL p12 (CFLAR) (modification, collaborate) Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FASLG (FASLG) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8) (modification, collaborate)
  Juo et al., Curr Biol 1998
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FASLG (FASLG) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, collaborate)
  Juo et al., Curr Biol 1998
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, collaborate)
  Juo et al., Curr Biol 1998
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, inhibits)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → RIP (RIPK1) (modification, collaborate) Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → clathrin heavy chain (CLTC) (translocation, collaborate)
  Algeciras-Schimnich et al., Mol Cell Biol 2002, Algeciras-Schimnich et al., FEBS Lett 2003, Lee et al., EMBO J 2006, Lavrik et al., J Biol Chem 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → FADD/FADD/CASP8/CASP8 complex (FADD-CASP8) (translocation, collaborate)
  Algeciras-Schimnich et al., Mol Cell Biol 2002, Algeciras-Schimnich et al., FEBS Lett 2003, Lee et al., EMBO J 2006, Lavrik et al., J Biol Chem 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → FASLG/FAS (trimer) complex (FAS-FASLG) (translocation, collaborate)
  Algeciras-Schimnich et al., Mol Cell Biol 2002, Algeciras-Schimnich et al., FEBS Lett 2003, Lee et al., EMBO J 2006, Lavrik et al., J Biol Chem 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → Ezrin (EZR) (translocation, collaborate) Algeciras-Schimnich et al., Mol Cell Biol 2002, Algeciras-Schimnich et al., FEBS Lett 2003, Lee et al., EMBO J 2006, Lavrik et al., J Biol Chem 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD/FADD/CASP8/CASP8 complex (FADD-CASP8) → FASLG/FAS (trimer) complex (FAS-FASLG) (translocation, collaborate)
  Algeciras-Schimnich et al., Mol Cell Biol 2002, Algeciras-Schimnich et al., FEBS Lett 2003, Lee et al., EMBO J 2006, Lavrik et al., J Biol Chem 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: c-FLIP (CFLAR) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, inhibits)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → RIP (RIPK1) (modification, collaborate) Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) (modification, inhibits)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, inhibits)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR) (modification, inhibits)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR) (modification, inhibits)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 8 (CASP8) → FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 8 (CASP8) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 8 (CASP8) → FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 8 (CASP8) → FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → c-FLIP (CFLAR) (modification, collaborate) Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → Caspase 8 p10 (CASP8) (modification, collaborate) Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → c-FLIP p12 (CFLAR) (modification, collaborate) Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: c-FLIP (CFLAR) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: c-FLIP (CFLAR) → FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: c-FLIP (CFLAR) → FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 8 p10 (CASP8) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 8 p10 (CASP8) → FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 8 p10 (CASP8) → FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) → FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) → FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) → c-FLIP p12 (CFLAR) (modification, collaborate) Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR) → FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR) (modification, collaborate)
  Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR) → c-FLIP p12 (CFLAR) (modification, collaborate) Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR) → c-FLIP p12 (CFLAR) (modification, collaborate) Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Kreuz et al., J Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: c-FLIPS (CFLAR) → FASLG/FAS (trimer)/FADD/FADD/CASP8/c-FLIPS complex (FAS-FASLG-FADD-CASP8-CFLAR) (modification, collaborate)
  Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
  Evidence: assay
• NCI Pathway Database FAS (CD95) signaling pathway: c-FLIPS (CFLAR) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
  Evidence: assay
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 8 (CASP8) → FASLG/FAS (trimer)/FADD/FADD/CASP8/c-FLIPS complex (FAS-FASLG-FADD-CASP8-CFLAR) (modification, collaborate)
  Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
  Evidence: assay
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 8 (CASP8) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
  Evidence: assay
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/c-FLIPS complex (FAS-FASLG-FADD-CASP8-CFLAR) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
  Evidence: assay
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Kischkel et al., EMBO J 1995, Vassilev et al., J Biol Chem 1999*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Kischkel et al., EMBO J 1995, Vassilev et al., J Biol Chem 1999*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer)/Btk complex (FAS-FASLG-BTK) (modification, collaborate)
  Kischkel et al., EMBO J 1995, Vassilev et al., J Biol Chem 1999*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Btk (BTK) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, collaborate)
  Kischkel et al., EMBO J 1995, Vassilev et al., J Biol Chem 1999*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Kischkel et al., EMBO J 1995, Vassilev et al., J Biol Chem 1999*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) → FASLG/FAS (trimer)/Btk complex (FAS-FASLG-BTK) (modification, collaborate)
  Kischkel et al., EMBO J 1995, Vassilev et al., J Biol Chem 1999*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Kreuz et al., J Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Wang et al., Proc Natl Acad Sci U S A 2001, Garg et al., Indian J Pediatr 1977, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Wang et al., Proc Natl Acad Sci U S A 2001, Garg et al., Indian J Pediatr 1977, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: c-FLIP (CFLAR) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, inhibits)
  Medema et al., EMBO J 1997
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) → Caspase 8 (4 units) complex (CASP8) (modification, activates)
  Medema et al., EMBO J 1997
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → Caspase 8 (tetramer)/FADD/FADD complex (CASP8-FADD) (modification, inhibits)
  Algeciras-Schimnich et al., Mol Cell Biol 2002, Cursi et al., EMBO J 2006*, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → FADD/FADD/CASP8/CASP8 complex (FADD-CASP8) (modification, inhibits)
  Algeciras-Schimnich et al., Mol Cell Biol 2002, Cursi et al., EMBO J 2006*, Medema et al., EMBO J 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → Caspase 8 (tetramer)/FADD/FADD complex (CASP8-FADD) (modification, inhibits)
  Cursi et al., EMBO J 2006*, Lavrik et al., J Biol Chem 2008, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, inhibits)
  Cursi et al., EMBO J 2006*, Lavrik et al., J Biol Chem 2008, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Caspase 8 (tetramer)/FADD/FADD complex (CASP8-FADD) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Cursi et al., EMBO J 2006*, Lavrik et al., J Biol Chem 2008, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: FADD → FAS (indirect_complex) Boldin et al., J Biol Chem 1995*
• Reactome Reaction: FADD → FAS (reaction) Boldin et al., J Biol Chem 1995*
• WikiPathways Alzheimers Disease: FAS/TNFRSF1A → FADD (activation)
• WikiPathways Nanomaterial induced apoptosis: FAS → FADD (activation)
• WikiPathways Apoptosis Modulation and Signaling: FAS → FADD (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: FADD — FAS Scaffidi et al., Methods 1999*
• IRef Bind_translation Interaction: FADD — FAS (unspecified method) Scaffidi et al., Methods 1999*
• IRef Bind_translation Interaction: FADD — FAS (coimmunoprecipitation) Uriarte et al., Cell Death Differ 2005*
• IRef Bind_translation Interaction: FADD — FAS (coimmunoprecipitation) Nam et al., Mol Cell 2004*
• IRef Biogrid Interaction: FADD — FAS (physical association, affinity chromatography technology) Chinnaiyan et al., Cell 1995*
• IRef Biogrid Interaction: FADD — FAS (physical association, affinity chromatography technology) Kumar et al., J Biol Chem 2001
• IRef Biogrid Interaction: FADD — FAS (physical association, affinity chromatography technology) Lee et al., Nature communications 2012
• IRef Biogrid Interaction: FADD — FAS (association, biochemical) Gajate et al., J Biol Chem 2005
• IRef Biogrid Interaction: FADD — FAS (physical association, affinity chromatography technology) Zhang et al., Free Radic Biol Med 2011*
• IRef Biogrid Interaction: FADD — FAS (direct interaction, pull down) Huang et al., Nature 1996*
• IRef Biogrid Interaction: FADD — FAS (association, x-ray crystallography) Huang et al., Nature 1996*
• IRef Biogrid Interaction: FADD — FAS (physical association, affinity chromatography technology) Pan et al., Science 1997*
• IRef Biogrid Interaction: FADD — FAS (physical association, affinity chromatography technology) MacFarlane et al., J Biol Chem 1997
• IRef Biogrid Interaction: FADD — FAS (direct interaction, two hybrid) Chinnaiyan et al., Cell 1995*
• IRef Biogrid Interaction: FADD — FAS (direct interaction, pull down) Chinnaiyan et al., Cell 1995*
• IRef Biogrid Interaction: FADD — FAS (direct interaction, two hybrid) Thomas et al., J Biol Chem 2002
• MIPS CORUM FAS-FADD-CASP8 complex: FAS-FADD-CASP8 complex complex (CASP8-FADD-FAS) Nam et al., Mol Cell 2004*
• MIPS CORUM Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced: Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced complex (CASP8-CFLAR-FADD-FAS) Lavrik et al., J Biol Chem 2008
• MIPS CORUM Death-inducing signaling complex DISC (type I cells associated), stimulated: Death-inducing signaling complex DISC (type I cells associated), stimulated complex (CASP8-FADD-FAS) Scaffidi et al., EMBO J 1998
• MIPS CORUM FAS-FADD-CASP8-CASP10 complex: FAS-FADD-CASP8-CASP10 complex complex (CASP10-CASP8-FADD-FAS) Wang et al., Proc Natl Acad Sci U S A 2001
• MIPS CORUM FAS-FADD-CASP8 complex: FAS-FADD-CASP8 complex complex (CASP8-FADD-FAS) Wang et al., Proc Natl Acad Sci U S A 2001
• MIPS CORUM FAS-FADD-CASP10 complex: FAS-FADD-CASP10 complex complex (CASP10-FADD-FAS) Wang et al., Proc Natl Acad Sci U S A 2001
• IRef Corum Interaction: Complex of 16 proteins (association, anti bait coimmunoprecipitation) Scaffidi et al., EMBO J 1998
• IRef Corum Interaction: Complex of FAS-FADD-CASP10 (association, fluorescent resonance energy transfer) Wang et al., Proc Natl Acad Sci U S A 2001
• IRef Dip Interaction: Complex of CASP8-FADD-FAS-YES1 (anti bait coimmunoprecipitation) Tauzin et al., PLoS Biol 2011*
• IRef Hprd Interaction: FADD — FAS (two hybrid) Feig et al., EMBO J 2007*, Scott et al., Nature 2009*, Boldin et al., J Biol Chem 1995*, Chinnaiyan et al., Cell 1995*, MacFarlane et al., J Biol Chem 1997
• IRef Hprd Interaction: FADD — FAS (in vivo) Feig et al., EMBO J 2007*, Scott et al., Nature 2009*, Boldin et al., J Biol Chem 1995*, Chinnaiyan et al., Cell 1995*, MacFarlane et al., J Biol Chem 1997
• IRef Hprd Interaction: FADD — FAS (in vitro) Feig et al., EMBO J 2007*, Scott et al., Nature 2009*, Boldin et al., J Biol Chem 1995*, Chinnaiyan et al., Cell 1995*, MacFarlane et al., J Biol Chem 1997
• IRef Hprd Interaction: Complex of FADD-FAS-CASP10-FADD-FADD-FAS-FAS-CASP10-CASP10 (in vivo) Vincenz et al., J Biol Chem 1997
• IRef Intact Interaction: FADD — FAS (physical association, anti tag coimmunoprecipitation) Chinnaiyan et al., Cell 1995*
• IRef Intact Interaction: FADD — FAS (direct interaction, molecular sieving) Scott et al., Nature 2009*
• IRef Intact Interaction: FADD — FAS (physical association, pull down) Wang et al., Nature structural & molecular biology 2010*
• IRef Intact Interaction: FADD — FAS (physical association, cosedimentation through density gradient) Wang et al., Nature structural & molecular biology 2010*
• IRef Intact Interaction: FADD — FAS (direct interaction, mass spectrometry studies of complexes) Wang et al., Nature structural & molecular biology 2010*
• IRef Intact Interaction: FADD — FAS (physical association, electron microscopy) Wang et al., Nature structural & molecular biology 2010*
• IRef Intact Interaction: FADD — FAS (physical association, two hybrid) Chinnaiyan et al., Cell 1995*
• IRef Intact Interaction: FADD — FAS (physical association, fluorescent resonance energy transfer) Wang et al., Nature structural & molecular biology 2010*
• IRef Intact Interaction: FADD — FAS (physical association, coimmunoprecipitation) Boldin et al., J Biol Chem 1995*
• IRef Intact Interaction: FADD — FAS (physical association, anti bait coimmunoprecipitation) Zhang et al., Free Radic Biol Med 2011*
• IRef Intact Interaction: FADD — FAS (physical association, two hybrid) Boldin et al., J Biol Chem 1995*
• IRef Intact Interaction: FADD — FAS (physical association, pull down) Chinnaiyan et al., Cell 1995*
• IRef Intact Interaction: FADD — FAS (physical association, pull down) Boldin et al., J Biol Chem 1995*
• IRef Intact Interaction: FADD — FAS (colocalization, imaging technique) Lee et al., EMBO J 2006
• IRef Intact Interaction: FADD — FAS (direct interaction, pull down) Scott et al., Nature 2009*
• IRef Intact Interaction: FADD — FAS (direct interaction, anti tag coimmunoprecipitation) Lee et al., EMBO J 2006
• IRef Intact Interaction: FADD — FAS (physical association, anti bait coimmunoprecipitation) Feig et al., EMBO J 2007*
• IRef Intact Interaction: FADD — FAS (physical association, anti bait coimmunoprecipitation) Kleber et al., Cancer Cell 2008*
• IRef Intact Interaction: FADD — FAS (direct interaction, cosedimentation) Scott et al., Nature 2009*
• IRef Intact Interaction: FADD — FAS (direct interaction, x-ray crystallography) Scott et al., Nature 2009*
• IRef Intact Interaction: Complex of FADD-FAS-CFLAR-CASP8 (association, anti bait coimmunoprecipitation) Tao et al., Blood 2011
• IRef Intact Interaction: Complex of CASP8-CASP8-FADD-FAS (association, anti bait coimmunoprecipitation) Shatnyeva et al., PloS one 2011*
• IRef Intact Interaction: Complex of 13 proteins (association, coimmunoprecipitation) Wang et al., Proc Natl Acad Sci U S A 2001
• IRef Intact Interaction: Complex of FASLG-FADD-FAS-CASP8 (association, anti tag coimmunoprecipitation) Micheau et al., Cell 2003
• IRef Intact Interaction: Complex of 17 proteins (association, anti bait coimmunoprecipitation) Tao et al., Blood 2011
• IRef Mppi Interaction: FADD — FAS (coimmunoprecipitation) Scaffidi et al., Methods 1999*
• IRef Ophid Interaction: FADD — FAS (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kabra et al., J Immunol 1999 (Splenomegaly) : These results suggest that FADD alone is sufficient for initiation of Fas signaling in primary T cells, but other pathways may operate in B cells
Charette et al., Mol Cell Biol 2000 : HSP27 expression had no effect on Fas induced FADD- and caspase dependent apoptosis
Werner et al., J Biol Chem 2002 : We conclude that FADD , caspase-8/10, and caspase cleaved Bid are required for TRAIL receptor and CD95 signaling to mitochondria, whereas Bax is a common accessory
Sprick et al., EMBO J 2002 : The involvement of the death adaptor protein FADD and the apoptosis initiating caspase-8 in CD95 and TRAIL death signalling has recently been demonstrated by the analysis of the native death inducing signalling complex ( DISC ) that forms upon ligand induced receptor cross linking
Papoff et al., Biochim Biophys Acta 2010 : Moreover, complementation experiments in Jurkat FADD-/- T cells indicated that : a ) cells expressing FADD mutants in the CaM binding sites are protected from Taxol induced G2/M cell cycle arrest ; b ) FADD/CaM interaction is not required for Fas receptor mediated apoptosis although Fas and CaM might compete for binding to FADD
Gupta et al., PloS one 2012 (Prostatic Neoplasms) : However, GTP induced FAS upregulation through activation of c-jun-N-terminal kinase resulted in FADD phosphorylation, caspase-8 activation and truncation of BID, leading to apoptosis in both LNCaPshV and LNCaPshp53 cells
Oh et al., J Immunol 2013 (Asthma) : Fas signaling strongly induced the phosphorylation of FADD at Ser ( 194 ) and Pin1 at Ser ( 16 ), as well as their nuclear accumulation
Wajant et al., Curr Biol 1998 : Dominant negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2 mediated cell death but not gene induction