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IL5 — STAT5A

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL5-mediated signaling events: IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2 complex (CSF2RB-IL5-IL5RA-JAK2) → STAT5 (STAT5A/STAT5B) (modification, activates) Mui et al., EMBO J 1995, Kouro et al., Int Immunol 1996
  Evidence: assay
• NCI Pathway Database IL5-mediated signaling events: IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2 complex (CSF2RB-IL5-IL5RA-JAK2) → STAT5-active (STAT5A/STAT5B) (modification, activates)
  Mui et al., EMBO J 1995, Kouro et al., Int Immunol 1996
  Evidence: assay
• Reactome Reaction: IL5 → STAT5A (reaction) Behrmann et al., J Biol Chem 1997, Flores-Morales et al., Mol Cell Endocrinol 1998
• Reactome Reaction: IL5 → STAT5A (indirect_complex)

Text-mined interactions from Literome

Ishihara et al., Int Arch Allergy Immunol 2000 : Treatment of eosinophils with IL-5 resulted in phosphorylation of STAT5 but not STAT1, and the IL-5 induced phosphorylation of STAT5 was inhibited by AG490
Bhattacharya et al., Am J Respir Cell Mol Biol 2001 : Granulocyte macrophage colony stimulating factor and interleukin-5 activate STAT5 and induce CIS1 mRNA in human peripheral blood eosinophils
Ishihara et al., Biochim Biophys Acta 2001 : Treatment of eosinophils with IL-5 resulted in phosphorylation of STAT5 but not STAT1, and the IL-5 induced phosphorylation of STAT5 was inhibited by AG490
Miura et al., J Immunol 2001 (MAP Kinase Signaling System) : However, only IL-3 and IL-5 induced Janus kinase 2 and STAT5 phosphorylation
Zhang et al., J Allergy Clin Immunol 2003 : In contrast, SNAP did not inhibit IL-5 induced STAT5 activation
Debierre-Grockiego et al., Br J Haematol 2003 : Activation of STAT5 by interleukin-5 was investigated during eosinophil differentiation
Stout et al., J Immunol 2004 : IL-5 and granulocyte-macrophage colony stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils
Mui et al., EMBO J 1995 : IL-5 and granulocyte-macrophage colony stimulating factor ( GM-CSF ), which share a common signaling receptor subunit with IL-3, also activate STAT5
Kouro et al., Int Immunol 1996 : Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5 mediated activation of JAK kinase and STAT5 ... In the studies described here, we demonstrate that IL-5 , IL-3 or GM-CSF stimulation induces the tyrosine phosphorylation of JAK2, and to a lesser extent JAK1, and of STAT5
Hoefsloot et al., Blood 1997 (Myelodysplastic Syndromes) : In contrast, interleukin-3 induced a normal STAT5 response in MDS cells
Ogata et al., Blood 1998 : IL-5 stimulation resulted in tyrosine phosphorylation of JAK2, JAK1, betac, and STAT5
Ozaki et al., Blood 1998 : Furthermore, interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and erythropoietin also induce Crkl-STAT5 complex formation in responding cells in a stimulation dependent manner