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FOS — RAC1
Text-mined interactions from Literome
Wroblewski et al., J Cell Sci 2003
(Neoplasm Invasiveness) :
RhoA acted through activation of both NF-kappaB and AP-1, whereas
Rac activated NF-kappaB but not
AP-1
Sakoda et al., J Dent Res 2006
:
Dominant negative
Rac1 severely
inhibited interleukin-1alpha induced NF-kappaB and
AP-1 promoter activity
Lee et al., Oncogene 2009
:
In summary, Galpha(12) and Galpha(13) regulate the expression of the TGFbeta1 gene through an increase in
Rho/Rac dependent
AP-1 activity, implying that the G-protein coupled receptor ( GPCR ) -Galpha(12) pathway is involved in the TGFbeta1 mediated transdifferentiation process
Nishita et al., Mol Cell Biol 2010
:
We further show that polymerized Dvl is colocalized with Rac1 and that suppressed expression of
Rac1 inhibits Wnt5a induced
AP-1 activation
Venkatesan et al., J Mol Cell Cardiol 2010
:
EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via
Rac1 dependent PI3K/Akt/IKK/NF-kappaB
andMKK7/JNK/AP-1 signaling
Collins et al., J Biol Chem 1996
:
In 1321N1 cells, where thrombin stimulates G12 dependent mitogenesis, coexpression of
N17Rac1 or a dominant negative mutant of MEKK1 ( MEKKDelta ( K432M ) )
inhibits c-Jun/AP-1 sensitive reporter gene expression stimulated by thrombin or Galpha12
Malliri et al., J Cell Biol 1998
:
Our data establish a novel link between
AP-1 activity and EGFR
activation of
Rac and Rho, which in turn mediate the actin cytoskeletal rearrangements required for cell motility and invasion